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- W1607149064 endingPage "188" @default.
- W1607149064 startingPage "163" @default.
- W1607149064 abstract "In eukaryotes, mitochondria carry out numerous functions that are central to cellular and organismal health. How mitochondrial activities are regulated in response to differing environmental conditions, such as variations in diet, remains an important unsolved question in biology. Here, we review emerging evidence suggesting that reversible acetylation of mitochondrial proteins on lysine residues represents a key mechanism by which mitochondrial functions are adjusted to meet environmental demands. In mammals, three members of the sirtuin class of NAD(+)-dependent deacetylases - SIRT3, SIRT4, and SIRT5 - localize to mitochondria and regulate targets involved in a diverse array of biochemical pathways. The importance of this activity is highlighted by recent studies of SIRT3 indicating that this protein suppresses the emergence of diverse age-related pathologies: hearing loss, cardiac fibrosis, and malignancy. Together, these findings argue that mitochondrial protein acetylation represents a central means by which mammals regulate mitochondrial functions to maintain cellular and organismal homeostasis." @default.
- W1607149064 created "2016-06-24" @default.
- W1607149064 creator A5015378345 @default.
- W1607149064 creator A5064668487 @default.
- W1607149064 creator A5082825241 @default.
- W1607149064 date "2011-01-01" @default.
- W1607149064 modified "2023-09-23" @default.
- W1607149064 title "Mitochondrial Sirtuins in the Regulation of Mitochondrial Activity and Metabolic Adaptation" @default.
- W1607149064 cites W1548851567 @default.
- W1607149064 cites W1762535185 @default.
- W1607149064 cites W1965935659 @default.
- W1607149064 cites W1966132436 @default.
- W1607149064 cites W1967148091 @default.
- W1607149064 cites W1968227588 @default.
- W1607149064 cites W1969855480 @default.
- W1607149064 cites W1970009760 @default.
- W1607149064 cites W1970060454 @default.
- W1607149064 cites W1977014064 @default.
- W1607149064 cites W1977199671 @default.
- W1607149064 cites W1978955254 @default.
- W1607149064 cites W1979048203 @default.
- W1607149064 cites W1979745754 @default.
- W1607149064 cites W1980268323 @default.
- W1607149064 cites W1981153918 @default.
- W1607149064 cites W1981549228 @default.
- W1607149064 cites W1984397718 @default.
- W1607149064 cites W1984942409 @default.
- W1607149064 cites W1985834536 @default.
- W1607149064 cites W1990295975 @default.
- W1607149064 cites W1991896842 @default.
- W1607149064 cites W1992913613 @default.
- W1607149064 cites W1996800526 @default.
- W1607149064 cites W1996914636 @default.
- W1607149064 cites W1999106865 @default.
- W1607149064 cites W1999524627 @default.
- W1607149064 cites W2000482070 @default.
- W1607149064 cites W2001457226 @default.
- W1607149064 cites W2003914125 @default.
- W1607149064 cites W2004351969 @default.
- W1607149064 cites W2004904888 @default.
- W1607149064 cites W2004923406 @default.
- W1607149064 cites W2004984537 @default.
- W1607149064 cites W2005828644 @default.
- W1607149064 cites W2009826707 @default.
- W1607149064 cites W2013841882 @default.
- W1607149064 cites W2017702083 @default.
- W1607149064 cites W2018912156 @default.
- W1607149064 cites W2021824743 @default.
- W1607149064 cites W2022101765 @default.
- W1607149064 cites W2022572059 @default.
- W1607149064 cites W2023444064 @default.
- W1607149064 cites W2025077643 @default.
- W1607149064 cites W2027271710 @default.
- W1607149064 cites W2029130907 @default.
- W1607149064 cites W2034641256 @default.
- W1607149064 cites W2037206515 @default.
- W1607149064 cites W2037678016 @default.
- W1607149064 cites W2042710774 @default.
- W1607149064 cites W2049547722 @default.
- W1607149064 cites W2052751736 @default.
- W1607149064 cites W2056673369 @default.
- W1607149064 cites W2056673958 @default.
- W1607149064 cites W2057194478 @default.
- W1607149064 cites W2057663429 @default.
- W1607149064 cites W2059750004 @default.
- W1607149064 cites W2063678700 @default.
- W1607149064 cites W2064921878 @default.
- W1607149064 cites W2065440747 @default.
- W1607149064 cites W2066317254 @default.
- W1607149064 cites W2066762257 @default.
- W1607149064 cites W2067367340 @default.
- W1607149064 cites W2067395327 @default.
- W1607149064 cites W2069269881 @default.
- W1607149064 cites W2073978750 @default.
- W1607149064 cites W2074037083 @default.
- W1607149064 cites W2075747312 @default.
- W1607149064 cites W2076186906 @default.
- W1607149064 cites W2076825983 @default.
- W1607149064 cites W2077864684 @default.
- W1607149064 cites W2078229478 @default.
- W1607149064 cites W2082740501 @default.
- W1607149064 cites W2083434423 @default.
- W1607149064 cites W2083650135 @default.
- W1607149064 cites W2084708023 @default.
- W1607149064 cites W2085743425 @default.
- W1607149064 cites W2086426033 @default.
- W1607149064 cites W2087439645 @default.
- W1607149064 cites W2087714970 @default.
- W1607149064 cites W2091457094 @default.
- W1607149064 cites W2095106276 @default.
- W1607149064 cites W2095235693 @default.
- W1607149064 cites W2099305647 @default.
- W1607149064 cites W2099547258 @default.
- W1607149064 cites W2100475243 @default.
- W1607149064 cites W2100476416 @default.
- W1607149064 cites W2101580126 @default.
- W1607149064 cites W2102186047 @default.
- W1607149064 cites W2102799140 @default.