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• W1607156738 abstract "Vasopressin (VP) secreted from parvocellular neurons of the hypothalamic paraventricular nucleus (PVN) stimulates pituitary adrenocorticotropic hormone (ACTH) secretion, through interaction with receptors of the V1b subtype (V1bR) in the pituitary corticotroph, mainly by potentiating the stimulatory effects of corticotrophin-releasing hormone (CRH). Chronic stress paradigms associated with corticotroph hyperresponsiveness lead to preferential expression of hypothalamic VP over CRH and upregulation of pituitary V1bR, suggesting that VP has a primary role during adaptation of the hypothalamic pituitary adrenal (HPA) axis to long-term stimulation. However, studies using pharmacological or genetic ablation of V1bR have shown that VP is required for full ACTH responses to some stressors, but not for the sensitization of ACTH responses to a novel stress observed during chronic stress. Studies using minipump infusion of a peptide V1 antagonist in long-term adrenalectomized rats have revealed that VP mediates proliferative responses in the pituitary. Nevertheless, only a minor proportion of cells undergoing mitogenesis co-express markers for differentiated corticotrophs or precursors, suggesting that new corticotrophs are recruited from yet undifferentiated cells. The overall evidence supports a limited role of VP regulating acute ACTH responses to some acute stressors and points to cell proliferation and pituitary remodelling as alternative roles for the marked increases in parvocellular vasopressinergic activity during prolonged activation of the HPA axis." @default.
• W1607156738 created "2016-06-24" @default.
• W1607156738 creator A5010779419 @default.
• W1607156738 creator A5024728856 @default.
• W1607156738 creator A5033628015 @default.
• W1607156738 creator A5082857859 @default.
• W1607156738 date "2008-01-01" @default.
• W1607156738 modified "2023-10-01" @default.
• W1607156738 title "The parvocellular vasopressinergic system and responsiveness of the hypothalamic pituitary adrenal axis during chronic stress" @default.
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• W1607156738 cites W1969886388 @default.
• W1607156738 cites W1972118398 @default.
• W1607156738 cites W1975616513 @default.
• W1607156738 cites W1981115977 @default.
• W1607156738 cites W1987553442 @default.
• W1607156738 cites W1989006745 @default.
• W1607156738 cites W1992886060 @default.
• W1607156738 cites W1993799056 @default.
• W1607156738 cites W1997819092 @default.
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• W1607156738 cites W2011477714 @default.
• W1607156738 cites W2013320836 @default.
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• W1607156738 cites W2018450379 @default.
• W1607156738 cites W2020164431 @default.
• W1607156738 cites W2023907117 @default.
• W1607156738 cites W2024670193 @default.
• W1607156738 cites W2024747936 @default.
• W1607156738 cites W2025171168 @default.
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• W1607156738 cites W2027002868 @default.
• W1607156738 cites W2031152730 @default.
• W1607156738 cites W2031934304 @default.
• W1607156738 cites W2032095869 @default.
• W1607156738 cites W2033472167 @default.
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• W1607156738 cites W2061538500 @default.
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• W1607156738 cites W2065361164 @default.
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• W1607156738 cites W2069145334 @default.
• W1607156738 cites W2069473761 @default.
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• W1607156738 cites W2088159839 @default.
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• W1607156738 cites W2130459724 @default.
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• W1607156738 doi "https://doi.org/10.1016/s0079-6123(08)00403-2" @default.
• W1607156738 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2536760" @default.
• W1607156738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18655869" @default.
• W1607156738 hasPublicationYear "2008" @default.
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