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• W1607157219 abstract "OBJECTIVE: The aim was to evaluate the interleukin (IL)‐27 levels in Helicobacter pylori ( H. pylori )‐infected patients with gastric ulcer (GU) or duodenal ulcer (DU) and to determine its association with H. pylori virulence factor cytotoxin‐associated gene A (CagA). METHODS: In all, 127 H. pylori infected patients (including 96 DU patients, of whom 61 were anti‐CagA + and 35 were anti‐CagA ‐ ) and 31 GU patients (of whom 15 were anti‐CagA + and 16 were anti‐CagA ‐ ), 60 asymptomatic (AS) carriers (of whom 30 were anti‐CagA + and 30 were anti‐CagA ‐ ) and 30 healthy H. pylori ‐negative participants (as a control) were enrolled in the study. Serum concentrations of IL‐27 were measured by the enzyme‐linked immunosorbent assay method. RESULTS: The mean levels of IL‐27 in the GU (44.26 ± 7.12 pg/mL) and DU patients (40.84 ± 3.90 pg/mL) was significantly higher than those observed in the AS carriers (22.06 ± 1.90 pg/mL, P < 0.001) and the control group (18.12 ± 1.68 pg/mL, P < 0.001 and P < 0.002, respectively). In the GU, DU and AS groups the levels of IL‐27 in anti‐CagA + participants were not significantly differ from that in the anti‐CagA ‐ participants. CONCLUSIONS: These results showed that the mean concentration of IL‐27 in H. pylori ‐infected peptic ulcer (PU) patients was higher than in AS carriers and the healthy control group. The serum concentrations of IL‐27 were not affected by the CagA factor." @default.
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• W1607157219 date "2011-07-25" @default.
• W1607157219 modified "2023-10-18" @default.
• W1607157219 title "Circulating interleukin-27 levels in Helicobacter pylori-infected patients with gastric or duodenal ulcers, independent of the bacterial cytotoxin-associated gene A virulence factor" @default.
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• W1607157219 doi "https://doi.org/10.1111/j.1751-2980.2011.00510.x" @default.
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