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• W1607172062 abstract "Elevated plasma myoinositol levels were induced in normal rats by feeding diets containing 35% myoinositol or by the repeated intraperitoneal injection of myoinositol. This reproducibly resulted in the development of decreased sciatic motor nerve conduction velocity without any initial change in the amplitude of the evoked muscle action potential or in whole nerve sensitivity to threshold stimulation. These observations suggest the development of dysfunction of the Schwann cell-myelin complex rather than of the axons or anterior horn cells. The recent recognition that hypermyoinositolemia is a common concomitant of human uremia, and the similarities in the electrophysiological derangements in peripheral nerve function in experimental hypermyoinositolemia and in subclinical uremic neuropathy suggest that elevated plasma myoinositol levels may contribute to the pathogenesis of uremic polyneuropathy." @default.
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• W1607172062 date "1974-03-01" @default.
• W1607172062 modified "2023-10-14" @default.
• W1607172062 title "Hypermyoinositolemic polyneuropathy in rats" @default.
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• W1607172062 doi "https://doi.org/10.1016/0022-510x(74)90170-1" @default.
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