Matches in SemOpenAlex for { <https://semopenalex.org/work/W1607172354> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W1607172354 endingPage "6281" @default.
- W1607172354 startingPage "6278" @default.
- W1607172354 abstract "Abstract This study attempts to identify the type and mechanism of RNA synthesis inhibited by N-hydroxy-2-acetylaminofluorene (N-OH-AAF). Two hours after the drug injection, the hepatic nuclear RNA synthesis was significantly inhibited when measured in intact nuclei in vitro. After the nuclei were sonicated and fractionated into nucleolar and nucleoplasmic fractions, it was found that the inhibitory effect was very slight in the nucleoplasmic fraction and was very extensive in the nucleolar fraction, where the inhibition by N-OH-AAF reached 90% 1 hour after the injection. Furthermore, when the endogenous template function of the nucleoli was abolished by actinomycin D and the RNA polymerase activity was determined in the presence of the exogenous synthetic template poly[d(A-T)], the polymerase activities of the nucleoli from the control and the carcinogen-treated animals became identical. These studies indicate that the inhibition of RNA synthesis, after acute N-OH-AAF treatment in vivo, is predominantly ribosomal RNA of nucleolar origin and is due to the impairment of the nucleolar DNA template function rather than to RNA polymerase per se." @default.
- W1607172354 created "2016-06-24" @default.
- W1607172354 creator A5025763524 @default.
- W1607172354 creator A5034509828 @default.
- W1607172354 creator A5078323974 @default.
- W1607172354 creator A5035287609 @default.
- W1607172354 date "1973-09-01" @default.
- W1607172354 modified "2023-10-15" @default.
- W1607172354 title "Mechanism of N-Hydroxy-2-acetylaminofluorene Inhibition of Rat Hepatic Ribonucleic Acid Synthesis" @default.
- W1607172354 cites W1437796291 @default.
- W1607172354 cites W1495358676 @default.
- W1607172354 cites W1511019847 @default.
- W1607172354 cites W184029216 @default.
- W1607172354 cites W1969699612 @default.
- W1607172354 cites W1976044291 @default.
- W1607172354 cites W1976522658 @default.
- W1607172354 cites W1989622567 @default.
- W1607172354 cites W1994394025 @default.
- W1607172354 cites W1995130076 @default.
- W1607172354 cites W2003393366 @default.
- W1607172354 cites W2019909042 @default.
- W1607172354 cites W2026912546 @default.
- W1607172354 cites W2037513274 @default.
- W1607172354 cites W2049334124 @default.
- W1607172354 cites W2058080707 @default.
- W1607172354 cites W2063971124 @default.
- W1607172354 cites W2084145961 @default.
- W1607172354 doi "https://doi.org/10.1016/s0021-9258(19)43444-3" @default.
- W1607172354 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4730322" @default.
- W1607172354 hasPublicationYear "1973" @default.
- W1607172354 type Work @default.
- W1607172354 sameAs 1607172354 @default.
- W1607172354 citedByCount "18" @default.
- W1607172354 crossrefType "journal-article" @default.
- W1607172354 hasAuthorship W1607172354A5025763524 @default.
- W1607172354 hasAuthorship W1607172354A5034509828 @default.
- W1607172354 hasAuthorship W1607172354A5035287609 @default.
- W1607172354 hasAuthorship W1607172354A5078323974 @default.
- W1607172354 hasBestOaLocation W16071723541 @default.
- W1607172354 hasConcept C111472728 @default.
- W1607172354 hasConcept C138885662 @default.
- W1607172354 hasConcept C153911025 @default.
- W1607172354 hasConcept C181199279 @default.
- W1607172354 hasConcept C185592680 @default.
- W1607172354 hasConcept C2779838395 @default.
- W1607172354 hasConcept C55493867 @default.
- W1607172354 hasConcept C86803240 @default.
- W1607172354 hasConcept C87644729 @default.
- W1607172354 hasConcept C89611455 @default.
- W1607172354 hasConceptScore W1607172354C111472728 @default.
- W1607172354 hasConceptScore W1607172354C138885662 @default.
- W1607172354 hasConceptScore W1607172354C153911025 @default.
- W1607172354 hasConceptScore W1607172354C181199279 @default.
- W1607172354 hasConceptScore W1607172354C185592680 @default.
- W1607172354 hasConceptScore W1607172354C2779838395 @default.
- W1607172354 hasConceptScore W1607172354C55493867 @default.
- W1607172354 hasConceptScore W1607172354C86803240 @default.
- W1607172354 hasConceptScore W1607172354C87644729 @default.
- W1607172354 hasConceptScore W1607172354C89611455 @default.
- W1607172354 hasIssue "18" @default.
- W1607172354 hasLocation W16071723541 @default.
- W1607172354 hasOpenAccess W1607172354 @default.
- W1607172354 hasPrimaryLocation W16071723541 @default.
- W1607172354 hasRelatedWork W1531601525 @default.
- W1607172354 hasRelatedWork W2319480705 @default.
- W1607172354 hasRelatedWork W2384464875 @default.
- W1607172354 hasRelatedWork W2606230654 @default.
- W1607172354 hasRelatedWork W2607424097 @default.
- W1607172354 hasRelatedWork W2748952813 @default.
- W1607172354 hasRelatedWork W2899084033 @default.
- W1607172354 hasRelatedWork W2948807893 @default.
- W1607172354 hasRelatedWork W4387497383 @default.
- W1607172354 hasRelatedWork W2778153218 @default.
- W1607172354 hasVolume "248" @default.
- W1607172354 isParatext "false" @default.
- W1607172354 isRetracted "false" @default.
- W1607172354 magId "1607172354" @default.
- W1607172354 workType "article" @default.