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- W16071757 endingPage "188" @default.
- W16071757 startingPage "157" @default.
- W16071757 abstract "Ascorbic acid is a low—molecular weight substance present in all aqueous compartments (cytosol, plasma, extracellular fluid) in animals and plants (Sies et al., 1992). Many invertebrates are not able to synthesize ascorbate, whereas the majority of vertebrates (amphibians, reptiles, birds, and mammals) synthesize ascorbate from glucose (Dabrowski, 1990). Since fishes do not synthesize ascorbate, the biosynthesis of this compound seems to have appeared during evolution in the amphibian kidney and moved afterward to the liver of mammals (Chatterjee, 1973). This classical view has been recently challenged by the finding that two primitive Actinopterigian fishes express the key enzyme of ascorbate synthesis and show no signs of scurvy when fed a vitamin C—deficient diet for 70 and 120 days. Thus, the bony fishes (Teleostei) would have lost their capacity for ascorbate synthesis after they separated during the Silurian from their common ancestor with the coelacanths (Latimeria) and Dipnoi lungfishes (Dabrowski, 1994). A few mammals (primates, humans, guinea pigs, and fruit-eating bats) and birds (passeriform) also lost the capacity to synthesize ascorbate and are dependent upon its presence in the diet. In these species the enzyme catalyzing the terminal step of synthesis of ascorbate from glucose in the liver by the D-glucuronic acid pathway, L-gulonolactone oxidase (E.C. 1.1.3.2.4.8.), is lacking. It has been reported that humans and guinea pigs lack the mRNA specific for this enzyme but that their genomes contain a DNA with a sequences related to the protein (Nishikimi et al., 1988)" @default.
- W16071757 created "2016-06-24" @default.
- W16071757 creator A5030906936 @default.
- W16071757 date "1996-01-01" @default.
- W16071757 modified "2023-10-16" @default.
- W16071757 title "Ascorbic Acid and Aging" @default.
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