FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1607236334> ?p ?o ?g. }

• W1607236334 endingPage "221" @default.
• W1607236334 startingPage "213" @default.
• W1607236334 abstract "Metabolic activation of 7-hydroxymethyl-12-methylbenz[a]anthracene (HMBA) and related hydroxymethyl polycyclic aromatic hydrocarbons to electrophilic and mutagenic sulfuric acid esters has been demonstrated previously (Watabe et al., In: Xenobiotic Metabolism and Disposition (Eds. Kato R, Estabrook RW and Cayen MN), pp. 393–400. Taylor & Francis, London, 1989). In the present study, the rat hepatic sulfotransferase activity catalyzing the formation of such reactive sulfuric acid esters was inhibited strongly by dehydroepiandrosterone, a typlcal substrate for hydroxysteroid sulfotransferases (HSSTs). Pentachlorophenol, a potent phenol sulfotransferase inhibitor, had little effect in this regard. A marked sex difference was observed for the hepatic cytosolic sulfotransferase activity for HMBA in rats. This sex difference was age-related; no significant difference was observed in preweanling rats, whereas in adult rats female rat liver showed a much higher enzyme activity. These age- and sex-related differences in the sulfonation of HMBA reflect the regulation of HMBA sulfotransferase activity by gonadal hormones as previously demonstrated with HSSTs. Thus, pretreatment with estradiol benzoate significantly enhanced the sulfotransferase activity for HMBA in both male and female rats, (P < 0.01 and P < 0.05 respectively), whereas testosterone propionate pretreatment decreased this activity. Castration of male rats increased the HMBA sulfotransferase activity 2- to 3-fold compared with that in control animals. By contrast, ovariectomy reduced the enzyme activity 38% in females. These results imply that rat liver HSST activity is responsible for the sulfonation of HMBA. Intraperitoneal injection of HMBA (0.25 μmol/g body wt) into infant rats produced benzylic DNA adducts in the liver which were chromatographically identical with those obtained from incubations of HMBA with deoxyguanosine and deoxyadenosine in the presence of hepatic cytosolic sulfotransferase activity. Intraperitoneal administration of sodium 7-sulfooxymethyl-12-methylbenz[a]anthracene resulted in much higher levels of these adducts and the deoxycytidine adduct in the liver DNA than did an equimolar amount of the parent hydroxymethyl hydrocarbon. The levels of hepatic benzylic DNA adducts formed from HMBA were reduced markedly by pretreatment of rats with dehydroepiandrosterone, a strong inhibitor of hepatic sulfotransferase activity for this hydrocarbon." @default.
• W1607236334 created "2016-06-24" @default.
• W1607236334 creator A5030586479 @default.
• W1607236334 creator A5037030117 @default.
• W1607236334 creator A5046704046 @default.
• W1607236334 creator A5061532156 @default.
• W1607236334 date "1991-01-01" @default.
• W1607236334 modified "2023-09-25" @default.
• W1607236334 title "Age- and sex-related differences in activation of the carcinogen 7-hydroxymethyl-12-methylbenz[a] anthracene to an electrophilic sulfuric acid ester metabolite in rats" @default.
• W1607236334 cites W1484967006 @default.
• W1607236334 cites W1512914303 @default.
• W1607236334 cites W1554639627 @default.
• W1607236334 cites W1600973584 @default.
• W1607236334 cites W1775749144 @default.
• W1607236334 cites W1968327603 @default.
• W1607236334 cites W1970509125 @default.
• W1607236334 cites W1972155718 @default.
• W1607236334 cites W1979863482 @default.
• W1607236334 cites W1980997741 @default.
• W1607236334 cites W1985257218 @default.
• W1607236334 cites W1990719318 @default.
• W1607236334 cites W1996203696 @default.
• W1607236334 cites W1997266569 @default.
• W1607236334 cites W2014424475 @default.
• W1607236334 cites W2024706581 @default.
• W1607236334 cites W2032120945 @default.
• W1607236334 cites W2037515649 @default.
• W1607236334 cites W2050645783 @default.
• W1607236334 cites W2061901688 @default.
• W1607236334 cites W2068946850 @default.
• W1607236334 cites W2087269467 @default.
• W1607236334 cites W2102187453 @default.
• W1607236334 cites W2117227109 @default.
• W1607236334 cites W2117485765 @default.
• W1607236334 cites W2142048068 @default.
• W1607236334 cites W2161668682 @default.
• W1607236334 cites W2163670995 @default.
• W1607236334 cites W2312263738 @default.
• W1607236334 cites W2316016234 @default.
• W1607236334 cites W2409407735 @default.
• W1607236334 cites W2086536535 @default.
• W1607236334 doi "https://doi.org/10.1016/0006-2952(91)90479-o" @default.
• W1607236334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1824923" @default.
• W1607236334 hasPublicationYear "1991" @default.
• W1607236334 type Work @default.
• W1607236334 sameAs 1607236334 @default.
• W1607236334 citedByCount "26" @default.
• W1607236334 countsByYear W16072363342016 @default.
• W1607236334 countsByYear W16072363342019 @default.
• W1607236334 crossrefType "journal-article" @default.
• W1607236334 hasAuthorship W1607236334A5030586479 @default.
• W1607236334 hasAuthorship W1607236334A5037030117 @default.
• W1607236334 hasAuthorship W1607236334A5046704046 @default.
• W1607236334 hasAuthorship W1607236334A5061532156 @default.
• W1607236334 hasConcept C114246631 @default.
• W1607236334 hasConcept C126322002 @default.
• W1607236334 hasConcept C134018914 @default.
• W1607236334 hasConcept C155138218 @default.
• W1607236334 hasConcept C185592680 @default.
• W1607236334 hasConcept C2775904581 @default.
• W1607236334 hasConcept C2777477808 @default.
• W1607236334 hasConcept C55493867 @default.
• W1607236334 hasConcept C71240020 @default.
• W1607236334 hasConcept C71924100 @default.
• W1607236334 hasConcept C86803240 @default.
• W1607236334 hasConceptScore W1607236334C114246631 @default.
• W1607236334 hasConceptScore W1607236334C126322002 @default.
• W1607236334 hasConceptScore W1607236334C134018914 @default.
• W1607236334 hasConceptScore W1607236334C155138218 @default.
• W1607236334 hasConceptScore W1607236334C185592680 @default.
• W1607236334 hasConceptScore W1607236334C2775904581 @default.
• W1607236334 hasConceptScore W1607236334C2777477808 @default.
• W1607236334 hasConceptScore W1607236334C55493867 @default.
• W1607236334 hasConceptScore W1607236334C71240020 @default.
• W1607236334 hasConceptScore W1607236334C71924100 @default.
• W1607236334 hasConceptScore W1607236334C86803240 @default.
• W1607236334 hasIssue "2" @default.
• W1607236334 hasLocation W16072363341 @default.
• W1607236334 hasLocation W16072363342 @default.
• W1607236334 hasOpenAccess W1607236334 @default.
• W1607236334 hasPrimaryLocation W16072363341 @default.
• W1607236334 hasRelatedWork W1712523681 @default.
• W1607236334 hasRelatedWork W2063679949 @default.
• W1607236334 hasRelatedWork W2142319763 @default.
• W1607236334 hasRelatedWork W2147593455 @default.
• W1607236334 hasRelatedWork W2161668682 @default.
• W1607236334 hasRelatedWork W2281003264 @default.
• W1607236334 hasRelatedWork W2409643735 @default.
• W1607236334 hasRelatedWork W2886656117 @default.
• W1607236334 hasRelatedWork W38747196 @default.
• W1607236334 hasRelatedWork W4233704945 @default.
• W1607236334 hasVolume "41" @default.
• W1607236334 isParatext "false" @default.
• W1607236334 isRetracted "false" @default.
• W1607236334 magId "1607236334" @default.
• W1607236334 workType "article" @default.