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- W1607316461 abstract "One aspect of this project set out to examine the effects of methamphetamine (METH) on the accumulation of cellular reactive oxygen species (ROS) and the expression of the mu-opioid receptor (MOR) in a dopaminergic cell line, SH-SY5Y, in order to delineate a possible role for ROS signaling in the coupling of dopaminergic and opioidergic pathways in neuronal cells. Prior evidence indicates neuronal cells treated with METH accumulate dopamine in the synaptic cleft which can lead to increased levels of ROS. Uncovering a role for ROS in increasing MOR expression in response to METH may provide a therapeutic target aimed at reducing the already established phenomenon of METH cross-sensitization to morphine, two drugs with high potential for abuse. A second aspect of this project investigated the mechanism by which lipopolysaccharide (LPS) exposure alters MOR expression in immune and neuronal cells. Previous research notes the exposure to LPS increases the production of ROS in murine macrophages. Also, activation of MOR effects functions associated with the immune response. Therefore, uncovering a role for ROS in increasing MOR expression in immune and neuronal cell types could provide additional insights in how to address problems associated with LPSinduced inflammatory response and the subsequent acceleration of sepsis seen with morphine treatment. The data presented here show that METH's effect on MOR expression is dependent upon sub-lethal levels of intracellular ROS increased by METH treatment, which suggests a possible coupling of METHand opiate-mediated intracellular signaling. In addition, work from the second portion of this project found that LPS stimulated the intracellular ROS accumulation and MOR expression in macrophage-like TPA-HL-60 cells. Conditioned medium from the LPS-stimulated TPA-HL-60 cells increased MOR expression in SH-SY5Y cells, a neuronal cell model, through actions mediated by TPA-HL-60 secreted TNF-a and GM-CSF. These data indicate that the endotoxin, LPS, modulates MOR expression in nervous and immune cells via ROS signaling, and demonstrates the crosstalk that exists within the neuroimmune axis." @default.
- W1607316461 created "2016-06-24" @default.
- W1607316461 creator A5024296993 @default.
- W1607316461 date "2011-01-01" @default.
- W1607316461 modified "2023-09-24" @default.
- W1607316461 title "Reactive Oxygen Species Modulation of the Mu-Opioid Receptor" @default.
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- W1607316461 cites W1569629748 @default.
- W1607316461 cites W1589589953 @default.
- W1607316461 cites W1708468382 @default.
- W1607316461 cites W1819355745 @default.
- W1607316461 cites W1827885532 @default.
- W1607316461 cites W1863566879 @default.
- W1607316461 cites W1870638847 @default.
- W1607316461 cites W1963627122 @default.
- W1607316461 cites W1967291007 @default.
- W1607316461 cites W1972293054 @default.
- W1607316461 cites W1973893152 @default.
- W1607316461 cites W1975434181 @default.
- W1607316461 cites W1975635890 @default.
- W1607316461 cites W1976428042 @default.
- W1607316461 cites W1979774071 @default.
- W1607316461 cites W1979947456 @default.
- W1607316461 cites W1981703791 @default.
- W1607316461 cites W1984111607 @default.
- W1607316461 cites W1984777669 @default.
- W1607316461 cites W1986046869 @default.
- W1607316461 cites W1988182239 @default.
- W1607316461 cites W1989109338 @default.
- W1607316461 cites W1989175790 @default.
- W1607316461 cites W1991514368 @default.
- W1607316461 cites W1995191054 @default.
- W1607316461 cites W1996385268 @default.
- W1607316461 cites W199781670 @default.
- W1607316461 cites W1998420008 @default.
- W1607316461 cites W1999543531 @default.
- W1607316461 cites W2009339203 @default.
- W1607316461 cites W2011837650 @default.
- W1607316461 cites W2016146035 @default.
- W1607316461 cites W2016906677 @default.
- W1607316461 cites W2018962880 @default.
- W1607316461 cites W2030104393 @default.
- W1607316461 cites W2031774759 @default.
- W1607316461 cites W2034157127 @default.
- W1607316461 cites W2040690369 @default.
- W1607316461 cites W2041587083 @default.
- W1607316461 cites W2043304786 @default.
- W1607316461 cites W2045010042 @default.
- W1607316461 cites W2048020456 @default.
- W1607316461 cites W2048484492 @default.
- W1607316461 cites W2051219234 @default.
- W1607316461 cites W2055021437 @default.
- W1607316461 cites W2056135909 @default.
- W1607316461 cites W2058388216 @default.
- W1607316461 cites W2060900794 @default.
- W1607316461 cites W2062042157 @default.
- W1607316461 cites W2062845561 @default.
- W1607316461 cites W2063342103 @default.
- W1607316461 cites W2071963896 @default.
- W1607316461 cites W2074891002 @default.
- W1607316461 cites W2077812249 @default.
- W1607316461 cites W2078524053 @default.
- W1607316461 cites W2078601258 @default.
- W1607316461 cites W2082548547 @default.
- W1607316461 cites W2083917106 @default.
- W1607316461 cites W2085572095 @default.
- W1607316461 cites W2093377694 @default.
- W1607316461 cites W2094729440 @default.
- W1607316461 cites W2105080299 @default.
- W1607316461 cites W2107277218 @default.
- W1607316461 cites W2111584592 @default.
- W1607316461 cites W2114238814 @default.
- W1607316461 cites W2118124014 @default.
- W1607316461 cites W2126208115 @default.
- W1607316461 cites W2126228551 @default.
- W1607316461 cites W2128903394 @default.
- W1607316461 cites W2129301007 @default.
- W1607316461 cites W2131466543 @default.
- W1607316461 cites W2135213970 @default.
- W1607316461 cites W2137135295 @default.
- W1607316461 cites W2139949932 @default.
- W1607316461 cites W2140872638 @default.
- W1607316461 cites W2141802124 @default.
- W1607316461 cites W2148094642 @default.
- W1607316461 cites W2163324649 @default.
- W1607316461 cites W2167521011 @default.
- W1607316461 cites W2169979796 @default.
- W1607316461 cites W2176833613 @default.
- W1607316461 cites W2273246438 @default.
- W1607316461 cites W2280276990 @default.
- W1607316461 cites W2309093247 @default.
- W1607316461 cites W2313541246 @default.
- W1607316461 cites W2407666542 @default.
- W1607316461 cites W2119458555 @default.
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