Matches in SemOpenAlex for { <https://semopenalex.org/work/W1607336507> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W1607336507 abstract "Conventional nitric oxide (NO) production by the muscle-specific isoform of neuronal NO synthase (nNOSμ) is greatly reduced in the dystrophin-deficient muscles of mdx mice and of patients with Duchenne muscular dystrophy (DMD). This loss of NO signaling renders the diseased muscles susceptible to ischemia during exercise due to unopposed sympathetic vasoconstriction. We therefore asked if NO-dependent functional sympatholysis could be restored in the contracting muscles of mdx mice using an alternate reductive pathway to generate NO from inorganic nitrate or nitrite. Norepinephrine (NE) evoked similar decreases in femoral vascular conductance (FVC) in the resting and contracting hindlimbs of untreated mdx mice, indicating functional muscle ischemia (ΔFVC contraction/rest: 0.85 ± 0.06, n = 15). After treatment with a single ip dose of nitrate or nitrite, NE evoked smaller decreases in FVC in the contracting versus resting hindlimbs, demonstrating restored sympatholysis (ΔFVC contraction/rest: nitrate-4 mg/kg, 0.50 ± 0.06; nitrate-8 mg/kg, 0.26 ± 0.07; and nitrite-0.2 mg/kg, 0.33 ± 0.07; n = 5 each). The beneficial effect of nitrite was prevented by co-administration of carboxy-PTIO to scavenge NO (n = 3), allopurinol to inhibit xanthine oxidase (n = 4) or raloxifene to inhibit aldehyde oxidase (n = 4). These findings indicate that the alternative nitrate-nitrite-NO pathway may be exploited to overcome reduced nNOSμ-NO signaling and improve blood flow regulation in the dystrophic muscles of mdx mice. Supported by DoD W81XWH-12-1-0256 and NIH AR056551." @default.
- W1607336507 created "2016-06-24" @default.
- W1607336507 creator A5011335360 @default.
- W1607336507 creator A5064564309 @default.
- W1607336507 date "2015-04-01" @default.
- W1607336507 modified "2023-09-25" @default.
- W1607336507 title "Inorganic Nitrate and Nitrite Restore Functional Sympatholysis in Dystrophin‐deficient Mdx Mice" @default.
- W1607336507 doi "https://doi.org/10.1096/fasebj.29.1_supplement.831.8" @default.
- W1607336507 hasPublicationYear "2015" @default.
- W1607336507 type Work @default.
- W1607336507 sameAs 1607336507 @default.
- W1607336507 citedByCount "0" @default.
- W1607336507 crossrefType "journal-article" @default.
- W1607336507 hasAuthorship W1607336507A5011335360 @default.
- W1607336507 hasAuthorship W1607336507A5064564309 @default.
- W1607336507 hasConcept C126322002 @default.
- W1607336507 hasConcept C134018914 @default.
- W1607336507 hasConcept C178790620 @default.
- W1607336507 hasConcept C181199279 @default.
- W1607336507 hasConcept C185592680 @default.
- W1607336507 hasConcept C199096232 @default.
- W1607336507 hasConcept C2776179834 @default.
- W1607336507 hasConcept C2776384668 @default.
- W1607336507 hasConcept C2778102346 @default.
- W1607336507 hasConcept C2778750056 @default.
- W1607336507 hasConcept C2778943923 @default.
- W1607336507 hasConcept C2779959927 @default.
- W1607336507 hasConcept C2779961880 @default.
- W1607336507 hasConcept C2780394045 @default.
- W1607336507 hasConcept C519581460 @default.
- W1607336507 hasConcept C55493867 @default.
- W1607336507 hasConcept C71924100 @default.
- W1607336507 hasConcept C98274493 @default.
- W1607336507 hasConceptScore W1607336507C126322002 @default.
- W1607336507 hasConceptScore W1607336507C134018914 @default.
- W1607336507 hasConceptScore W1607336507C178790620 @default.
- W1607336507 hasConceptScore W1607336507C181199279 @default.
- W1607336507 hasConceptScore W1607336507C185592680 @default.
- W1607336507 hasConceptScore W1607336507C199096232 @default.
- W1607336507 hasConceptScore W1607336507C2776179834 @default.
- W1607336507 hasConceptScore W1607336507C2776384668 @default.
- W1607336507 hasConceptScore W1607336507C2778102346 @default.
- W1607336507 hasConceptScore W1607336507C2778750056 @default.
- W1607336507 hasConceptScore W1607336507C2778943923 @default.
- W1607336507 hasConceptScore W1607336507C2779959927 @default.
- W1607336507 hasConceptScore W1607336507C2779961880 @default.
- W1607336507 hasConceptScore W1607336507C2780394045 @default.
- W1607336507 hasConceptScore W1607336507C519581460 @default.
- W1607336507 hasConceptScore W1607336507C55493867 @default.
- W1607336507 hasConceptScore W1607336507C71924100 @default.
- W1607336507 hasConceptScore W1607336507C98274493 @default.
- W1607336507 hasFunder F4320306078 @default.
- W1607336507 hasFunder F4320332161 @default.
- W1607336507 hasIssue "S1" @default.
- W1607336507 hasLocation W16073365071 @default.
- W1607336507 hasOpenAccess W1607336507 @default.
- W1607336507 hasPrimaryLocation W16073365071 @default.
- W1607336507 hasRelatedWork W1607336507 @default.
- W1607336507 hasRelatedWork W192758783 @default.
- W1607336507 hasRelatedWork W1988999122 @default.
- W1607336507 hasRelatedWork W1999014003 @default.
- W1607336507 hasRelatedWork W2055518329 @default.
- W1607336507 hasRelatedWork W2059574464 @default.
- W1607336507 hasRelatedWork W2087240517 @default.
- W1607336507 hasRelatedWork W2113505793 @default.
- W1607336507 hasRelatedWork W2131396113 @default.
- W1607336507 hasRelatedWork W3175638568 @default.
- W1607336507 hasVolume "29" @default.
- W1607336507 isParatext "false" @default.
- W1607336507 isRetracted "false" @default.
- W1607336507 magId "1607336507" @default.
- W1607336507 workType "article" @default.