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- W1607388525 abstract "<h3>Abstract</h3> Telomeres are bound by dedicated protein complexes, like shelterin in mammals, which protect telomeres from DNA damage. In the nematode <i>Caenorhabditis elegans</i>, a comprehensive understanding of the proteins interacting with the telomere sequence is lacking. Here, we harnessed a quantitative proteomics approach to screen for proteins binding to <i>C. elegans telomeres</i>, and identified TEBP-1 and TEBP-2, two paralogs that associate to telomeres in vitro and in vivo. TEBP-1 and TEBP-2 are expressed in the germline and during embryogenesis. <i>tebp-1</i> and <i>tebp-2</i> mutants display strikingly distinct phenotypes: <i>tebp-1</i> mutants have longer telomeres than wild-type animals, while <i>tebp-2</i> mutants display shorter telomeres and a mortal germline, a phenotype characterized by transgenerational germline deterioration. Notably, <i>tebp-1</i>; <i>tebp-2</i> double mutant animals have synthetic sterility, with germlines showing signs of severe mitotic and meiotic arrest. TEBP-1 and TEBP-2 form a telomeric complex with the known single-stranded telomere-binding proteins POT-1, POT-2, and MRT-1. Furthermore, we find that POT-1 bridges the double- stranded binders TEBP-1 and TEBP-2, with the single-stranded binders POT-2 and MRT-1. These results describe the first telomere-binding complex in <i>C. elegans</i>, with TEBP-1 and TEBP-2, two double-stranded telomere binders required for fertility and that mediate opposite telomere dynamics." @default.
- W1607388525 created "2016-06-24" @default.
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- W1607388525 date "2003-12-06" @default.
- W1607388525 modified "2023-10-11" @default.
- W1607388525 title "Missing women--revisited" @default.
- W1607388525 cites W2151051050 @default.
- W1607388525 doi "https://doi.org/10.1136/bmj.327.7427.1297" @default.
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