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- W1607471013 endingPage "268" @default.
- W1607471013 startingPage "237" @default.
- W1607471013 abstract "Abstract The chapter provides a comprehensive review of the current knowledge concerning the anatomical, physiological, and neurochemical substrates that underlie both physiological and pathological pain. Thus, we describe in detail the pathways that underlie the transmission of inputs from the periphery to the CNS, the physiological properties of the neurons activated by painful stimuli, and the neurochemicals that mediate or modulate synaptic transmission in somatosensory pathways. A special effort has been made to identify critical advances in the field of pain research that point to the processes by which pathological pain develops following tissue or nerve injury, as well as how pain is modulated by various brain mechanisms. The review of the peripheral nervous system concentrates on differences in the properties of the primary afferent neurons that transduce and relay painful messages to the CNS, and how their responses are affected by injuries that produce inflammation. The review of spinal cord dorsal horn concentrates on what is known about the neurochemical influences on synaptic transmission, and how they are affected by inflammatory and nerve injuries in the periphery. The review of pain processing in the brain focuses on the role of various brain regions in the determination of the multidimensional nature of pain, as discerned by anatomical connectivity, physiological function, and brain imaging. Finally, insights are provided into the future of pain research, with a focus on molecular biology, and behavioral genetics as a means to understand individual differences in pain sensitivity and expression." @default.
- W1607471013 created "2016-06-24" @default.
- W1607471013 creator A5005776897 @default.
- W1607471013 creator A5053847400 @default.
- W1607471013 creator A5061453212 @default.
- W1607471013 date "2003-04-15" @default.
- W1607471013 modified "2023-09-23" @default.
- W1607471013 title "The Biological Psychology of Pain" @default.
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