FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1607524461> ?p ?o ?g. }

• W1607524461 abstract "The rapid accumulation of sequenced genomes offers the chance to resolve longstanding questions about the evolutionary histories, or phylogenies, of groups of organisms. The relatively rare occurrence of large-scale evolutionary events in a whole genome, events such as genome rearrangements, duplications and losses, enables us to extract a strong and robust phylogenetic signal from whole-genome data. The work presented in this dissertation focuses on models and algorithms for whole-genome evolution and their use in phylogenetic inference. We designed algorithms to estimate pairwise genomic distances from large-scale genomic changes. We refined the evolutionary models on whole-genome evolution. We also made use of these results to provide fast and accurate methods for phylogenetic inference, that scales up, in both speed and accuracy, to modern high-resolution whole-genome data. We designed algorithms to estimate the true evolutionary distance between two genomes under genome rearrangements, and also under rearrangements, plus gains and losses. We refined the evolutionary model to be the first mathematical model to preserve the structural dichotomy in genomic organization between most prokaryotes and most eukaryotes. Those models and associated distance estimators provide a basis for studying facets of possible mechanisms of evolution through simulation and application to real genomes. Phylogenetic analyses from whole-genome data have been limited to small collections of genomes and low-resolution data; they have also lacked an effective assessment of robustness. We developed an approach that combines our distance estimator, any standard distance-based reconstruction algorithm, and a novel bootstrapping method based on resampling genomic adjacencies. The resulting tool overcomes a serious and long-standing impediment to the use of whole-genome data in phylogenetic inference and provides results comparable in accuracy and robustness to distance-based methods for sequence data. Maximum-likelihood approaches have been successfully applied to phylogenetic inferences for aligned sequences, but such applications remain primitive for whole-genome data. We developed a maximum-likelihood approach to phylogenetic analysis from whole-genome data. In combination with our bootstrap scheme, this new approach yields the first reliable phylogenetic tool for the analysis of whole-genome data at the level of syntenic blocks." @default.
• W1607524461 created "2016-06-24" @default.
• W1607524461 creator A5079714822 @default.
• W1607524461 date "2012-01-01" @default.
• W1607524461 modified "2023-09-23" @default.
• W1607524461 title "Models and Algorithms for Whole-Genome Evolution and their Use in Phylogenetic Inference" @default.
• W1607524461 cites W1491688952 @default.
• W1607524461 cites W1504968226 @default.
• W1607524461 cites W1507091143 @default.
• W1607524461 cites W1511771787 @default.
• W1607524461 cites W1519987066 @default.
• W1607524461 cites W152315924 @default.
• W1607524461 cites W1525734744 @default.
• W1607524461 cites W1530804984 @default.
• W1607524461 cites W1547622250 @default.
• W1607524461 cites W1554477894 @default.
• W1607524461 cites W1555623370 @default.
• W1607524461 cites W1572531572 @default.
• W1607524461 cites W1585116395 @default.
• W1607524461 cites W1585881831 @default.
• W1607524461 cites W1589174490 @default.
• W1607524461 cites W1592788845 @default.
• W1607524461 cites W1594983821 @default.
• W1607524461 cites W1606486549 @default.
• W1607524461 cites W1656398202 @default.
• W1607524461 cites W1890701999 @default.
• W1607524461 cites W1963847479 @default.
• W1607524461 cites W1972412557 @default.
• W1607524461 cites W1973186137 @default.
• W1607524461 cites W1976927254 @default.
• W1607524461 cites W1981231088 @default.
• W1607524461 cites W1981492171 @default.
• W1607524461 cites W1981509964 @default.
• W1607524461 cites W1982970543 @default.
• W1607524461 cites W1984347506 @default.
• W1607524461 cites W1995945562 @default.
• W1607524461 cites W1996816368 @default.
• W1607524461 cites W1999269351 @default.
• W1607524461 cites W2006355424 @default.
• W1607524461 cites W2006820723 @default.
• W1607524461 cites W2009596137 @default.
• W1607524461 cites W2013783433 @default.
• W1607524461 cites W2015472416 @default.
• W1607524461 cites W2015800458 @default.
• W1607524461 cites W2020350008 @default.
• W1607524461 cites W2020891730 @default.
• W1607524461 cites W2022394456 @default.
• W1607524461 cites W2024305671 @default.
• W1607524461 cites W2025489760 @default.
• W1607524461 cites W2026452889 @default.
• W1607524461 cites W2027840499 @default.
• W1607524461 cites W2029423003 @default.
• W1607524461 cites W2029943378 @default.
• W1607524461 cites W2030966943 @default.
• W1607524461 cites W2041797002 @default.
• W1607524461 cites W2045017146 @default.
• W1607524461 cites W2049796549 @default.
• W1607524461 cites W2051578566 @default.
• W1607524461 cites W2055257453 @default.
• W1607524461 cites W2057729471 @default.
• W1607524461 cites W2060425093 @default.
• W1607524461 cites W2060973867 @default.
• W1607524461 cites W2065461553 @default.
• W1607524461 cites W2065691269 @default.
• W1607524461 cites W2067249552 @default.
• W1607524461 cites W2081742431 @default.
• W1607524461 cites W2082638565 @default.
• W1607524461 cites W2084215753 @default.
• W1607524461 cites W2086532189 @default.
• W1607524461 cites W2090074287 @default.
• W1607524461 cites W2095815023 @default.
• W1607524461 cites W2097082463 @default.
• W1607524461 cites W2097412226 @default.
• W1607524461 cites W2097706568 @default.
• W1607524461 cites W2098276108 @default.
• W1607524461 cites W2098448352 @default.
• W1607524461 cites W2102424972 @default.
• W1607524461 cites W2102813451 @default.
• W1607524461 cites W2103546861 @default.
• W1607524461 cites W2103849916 @default.
• W1607524461 cites W2105556779 @default.
• W1607524461 cites W2106151976 @default.
• W1607524461 cites W2106179083 @default.
• W1607524461 cites W2106228995 @default.
• W1607524461 cites W2108998942 @default.
• W1607524461 cites W2116794821 @default.
• W1607524461 cites W2117897510 @default.
• W1607524461 cites W2119500092 @default.
• W1607524461 cites W2120819924 @default.
• W1607524461 cites W2122004093 @default.
• W1607524461 cites W2122112080 @default.
• W1607524461 cites W2122903088 @default.
• W1607524461 cites W2124181495 @default.
• W1607524461 cites W2126769883 @default.
• W1607524461 cites W2131071295 @default.
• W1607524461 cites W2131459995 @default.
• W1607524461 cites W2133090982 @default.
• W1607524461 cites W2140222156 @default.
• W1607524461 cites W2143335572 @default.
• W1607524461 cites W2144958703 @default.

• next