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• W1607672258 abstract "Motor-skill learning induces changes in synaptic structure and function in the primary motor cortex through the involvement of a long-term potentiation- (LTP-) like mechanism. Although there is evidence that calcium-dependent release of gliotransmitters by astrocytes plays an important role in synaptic transmission and plasticity, the role of astrocytes in motor-skill learning is not known. To test the hypothesis that astrocytic activity is necessary for motor-skill learning, we perturbed astrocytic function using pharmacological and genetic approaches. We find that perturbation of astrocytes either by selectively attenuating IP 3 R2 mediated astrocyte Ca 2+ signaling or using an astrocyte specific metabolic inhibitor fluorocitrate (FC) results in impaired motor-skill learning of a forelimb reaching-task in mice. Moreover, the learning impairment caused by blocking astrocytic activity using FC was rescued by administration of the gliotransmitter D-serine. The learning impairments are likely caused by impaired LTP as FC blocked LTP in slices and prevented motor-skill training-induced increases in synaptic AMPA-type glutamate receptor in vivo . These results support the conclusion that normal astrocytic Ca 2+ signaling during a reaching task is necessary for motor-skill learning." @default.
• W1607672258 created "2016-06-24" @default.
• W1607672258 creator A5026059837 @default.
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• W1607672258 date "2015-01-01" @default.
• W1607672258 modified "2023-10-16" @default.
• W1607672258 title "Motor-Skill Learning Is Dependent on Astrocytic Activity" @default.
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• W1607672258 doi "https://doi.org/10.1155/2015/938023" @default.
• W1607672258 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4539503" @default.
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