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- W1607718981 abstract "Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by polyclonal B-cell activation, autoantibody production and immune complex-mediated glomerulonephritis(GN). NZB/W F1 mice spontaneously develop SLE-like syndromes and have been widely used as an animal model for SLE. Even though the etiologic cause of autoimmunity in both human and murine lupus is not clearly understood, mounting evidence indicates the involvement of autoreactive B cells and T cells. Blockade of costimulatory pathways using CTLA4Ig fusion protein and anti-CD40 ligand mAb was able to suppress autoantibody production and inhibit neprhitis in NZB/W F1 mice. However, for such a chronic disease long term intervention is necessary and gene therapy may be advantageous." @default.
- W1607718981 created "2016-06-24" @default.
- W1607718981 date "2004-05-01" @default.
- W1607718981 modified "2023-09-26" @default.
- W1607718981 title "AAV-mediated gene therapy for systemic lupus erythematosus (SLE)" @default.
- W1607718981 doi "https://doi.org/10.1016/j.ymthe.2004.05.061" @default.
- W1607718981 hasPublicationYear "2004" @default.
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