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• W1607785571 abstract "Although epidemiological studies in shift workers and flight attendants have associated chronic circadian rhythm disturbance (CRD) with increased breast cancer risk, causal evidence for this association is lacking [1Pukkala E. Auvinen A. Wahlberg G. Incidence of cancer among Finnish airline cabin attendants, 1967-92.BMJ. 1995; 311: 649-652Crossref PubMed Scopus (214) Google Scholar, 2Schernhammer E.S. Kroenke C.H. Laden F. Hankinson S.E. Night work and risk of breast cancer.Epidemiology. 2006; 17: 108-111Crossref PubMed Scopus (398) Google Scholar]. Several scenarios have been proposed to contribute to the shift work-cancer connection: (1) internal desynchronization, (2) light at night (resulting in melatonin suppression), (3) sleep disruption, (4) lifestyle disturbances, and (5) decreased vitamin D levels due to lack of sunlight [3Fritschi L. Glass D.C. Heyworth J.S. Aronson K. Girschik J. Boyle T. Grundy A. Erren T.C. Hypotheses for mechanisms linking shiftwork and cancer.Med. Hypotheses. 2011; 77: 430-436Abstract Full Text Full Text PDF PubMed Scopus (150) Google Scholar]. The confounders inherent in human field studies are less problematic in animal studies, which are therefore a good approach to assess the causal relation between circadian disturbance and cancer. However, the experimental conditions of many of these animal studies were far from the reality of human shift workers. For example, some involved xenografts (addressing tumor growth rather than cancer initiation and/or progression) [4Blask D.E. Dauchy R.T. Sauer L.A. Krause J.A. Brainard G.C. Growth and fatty acid metabolism of human breast cancer (MCF-7) xenografts in nude rats: impact of constant light-induced nocturnal melatonin suppression.Breast Cancer Res. Treat. 2003; 79: 313-320Crossref PubMed Scopus (104) Google Scholar, 5Filipski E. Delaunay F. King V.M. Wu M.W. Claustrat B. Gréchez-Cassiau A. Guettier C. Hastings M.H. Francis L. Effects of chronic jet lag on tumor progression in mice.Cancer Res. 2004; 64: 7879-7885Crossref PubMed Scopus (320) Google Scholar], chemically induced tumor models [6Hamilton T. Influence of environmental light and melatonin upon mammary tumour induction.Br. J. Surg. 1969; 56: 764-766Crossref PubMed Scopus (75) Google Scholar, 7Shah P.N. Mhatre M.C. Kothari L.S. Effect of melatonin on mammary carcinogenesis in intact and pinealectomized rats in varying photoperiods.Cancer Res. 1984; 44: 3403-3407PubMed Google Scholar], or continuous bright light exposure, which can lead to suppression of circadian rhythmicity [8Anisimov V.N. Baturin D.A. Popovich I.G. Zabezhinski M.A. Manton K.G. Semenchenko A.V. Yashin A.I. Effect of exposure to light-at-night on life span and spontaneous carcinogenesis in female CBA mice.Int. J. Cancer. 2004; 111: 475-479Crossref PubMed Scopus (56) Google Scholar, 9Wu J. Dauchy R.T. Tirrell P.C. Wu S.S. Lynch D.T. Jitawatanarat P. Burrington C.M. Dauchy E.M. Blask D.E. Greene M.W. Light at night activates IGF-1R/PDK1 signaling and accelerates tumor growth in human breast cancer xenografts.Cancer Res. 2011; 71: 2622-2631Crossref PubMed Scopus (58) Google Scholar]. Here, we have exposed breast cancer-prone p53R270H©/+ WAPCre conditional mutant mice (in a FVB genetic background) to chronic CRD by subjecting them to a weekly alternating light-dark (LD) cycle throughout their life. Animals exposed to the weekly LD inversions showed a decrease in tumor suppression. In addition, these animals showed an increase in body weight. Importantly, this study provides the first experimental proof that CRD increases breast cancer development. Finally, our data suggest internal desynchronization and sleep disturbance as mechanisms linking shift work with cancer development and obesity." @default.
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• W1607785571 date "2015-07-01" @default.
• W1607785571 modified "2023-10-16" @default.
• W1607785571 title "Chronically Alternating Light Cycles Increase Breast Cancer Risk in Mice" @default.
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• W1607785571 doi "https://doi.org/10.1016/j.cub.2015.06.012" @default.
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