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- W1607952539 abstract "Abstract During the past decades various incidents with dioxins and dioxin-like PCBs have drawn the attention of the general public. In addition to occupational exposure, some of these compounds accumulate in the food chain and cause a number of adverse effects in animals and humans. This includes effects on the sexual development and the thyroid, allowing their classification as endocrine disruptors. Although it is evident that the arylhydrocarbon (Ah) receptor plays a crucial role in the toxic effects, the exact mechanism is still unclear. Based on the effects on sperm counts in the male offspring of treated dams, an exposure limit has been set corresponding to about 2 pg TEQ/kg body weight/day. At present the margin between the actual exposure and the exposure limit is small and even non-existent for part of the population. As a result the EU has set strict limits for feed and food in order to further reduce the exposure. Current levels are declining. However, at the same time a number of new compounds have been shown to be persistent like the brominated flame retardants. These compounds too have been shown to affect the thyroid of animals. At present no exposure limit has been established but margins between exposure of human consumers and effect levels in animals appear to be large, although these calculations do not take into account potential differences in kinetics. In addition the production and incineration of polybromodiphenylethers (PBDEs) may result in the formation of bromodioxins with similar adverse effects as their chlorinated counterparts." @default.
- W1607952539 created "2016-06-24" @default.
- W1607952539 creator A5044310469 @default.
- W1607952539 date "2009-01-01" @default.
- W1607952539 modified "2023-09-25" @default.
- W1607952539 title "Dioxins, polychlorinated biphenyls and brominated flame retardants" @default.
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- W1607952539 doi "https://doi.org/10.1533/9781845695743.4.383" @default.
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