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- W1607988052 abstract "Summary We have analysed the transposition and target selection strategy of IS 1655 , a typical IS 30 family member resident in Neisseria meningitidis . We have redefined IS 1655 as a 1080 bp long element with 25 bp imperfect inverted repeats (IRs), which generates a 3 bp target duplication and have shown that it transposes using an intermediate with abutted IRs separated by 2 bp. IS 1655 exhibits bipartite target specificity inserting preferentially either next to sequences similar to its IRs or into an unrelated but well defined sequence. IR‐targeting leads to the formation of a new junction in which the targeted IR and one of the donor IRs are separated by 2 bp. The non‐IR targets were characterized as an imperfect 19 bp palindrome in which the central five positions show slight GC excess and the distal region is AT‐rich. Artificial targets designed according to the consensus were recognized by the element as hot spots for insertion. The organization of IS 1655 is similar to that of other IS 30 family members. Moreover, it shows striking similarity to IS 30 in transposition strategy even though their transposases differ in their N‐terminal regions, which, for IS 30 , appears to determine target specificity. Comparative analysis of the transposases and the evolutionary aspects of sequence variants are also briefly discussed." @default.
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- W1607988052 date "2007-01-22" @default.
- W1607988052 modified "2023-10-16" @default.
- W1607988052 title "Transposition and target specificity of the typical IS30 family element IS1655 from Neisseria meningitidis" @default.
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- W1607988052 doi "https://doi.org/10.1111/j.1365-2958.2007.05621.x" @default.
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