Matches in SemOpenAlex for { <https://semopenalex.org/work/W1607992452> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W1607992452 endingPage "321" @default.
- W1607992452 startingPage "320" @default.
- W1607992452 abstract "Under the Human Genome Project, a rough draft of the human genome will be sequenced in 2000, and almost all in 2003. The next step is to obtain functions of the genes in the genome. Structural genomics and pharmacogenomics are among the promising approaches to elucidate them. A gene function is regarded as the protein function and thus the atomic configurations in functional sites of the protein. The functional sites usually include specific binding sites of ligands, especially small molecules. Therefore the collection and organization of local structural knowledge, including atomic locations of ligands and interacting sites of proteins and ligands, must be a precious resource for computational drug design. We have constructed a library of protein-ligand interaction sites and a scoring system for compounds [1]. We report here an improvement of the library, which now contains the information on substructures and functional groups (functional units) of ligand. We also report the improved scoring scheme. We believe this scoring system can be applied to the drug design by combining the predefined functional units." @default.
- W1607992452 created "2016-06-24" @default.
- W1607992452 creator A5026586100 @default.
- W1607992452 creator A5044731487 @default.
- W1607992452 creator A5058022821 @default.
- W1607992452 date "1999-01-01" @default.
- W1607992452 modified "2023-09-25" @default.
- W1607992452 title "Unit-Based de novo Drug Design Using a Library of Protein-Ligand Interaction Sites" @default.
- W1607992452 cites W1966041739 @default.
- W1607992452 hasPublicationYear "1999" @default.
- W1607992452 type Work @default.
- W1607992452 sameAs 1607992452 @default.
- W1607992452 citedByCount "0" @default.
- W1607992452 crossrefType "journal-article" @default.
- W1607992452 hasAuthorship W1607992452A5026586100 @default.
- W1607992452 hasAuthorship W1607992452A5044731487 @default.
- W1607992452 hasAuthorship W1607992452A5058022821 @default.
- W1607992452 hasConcept C104317684 @default.
- W1607992452 hasConcept C116569031 @default.
- W1607992452 hasConcept C14036430 @default.
- W1607992452 hasConcept C141231307 @default.
- W1607992452 hasConcept C161078062 @default.
- W1607992452 hasConcept C170493617 @default.
- W1607992452 hasConcept C170734499 @default.
- W1607992452 hasConcept C189206191 @default.
- W1607992452 hasConcept C192772702 @default.
- W1607992452 hasConcept C197077220 @default.
- W1607992452 hasConcept C41008148 @default.
- W1607992452 hasConcept C47701112 @default.
- W1607992452 hasConcept C54355233 @default.
- W1607992452 hasConcept C55493867 @default.
- W1607992452 hasConcept C60644358 @default.
- W1607992452 hasConcept C70721500 @default.
- W1607992452 hasConcept C74187038 @default.
- W1607992452 hasConcept C86803240 @default.
- W1607992452 hasConceptScore W1607992452C104317684 @default.
- W1607992452 hasConceptScore W1607992452C116569031 @default.
- W1607992452 hasConceptScore W1607992452C14036430 @default.
- W1607992452 hasConceptScore W1607992452C141231307 @default.
- W1607992452 hasConceptScore W1607992452C161078062 @default.
- W1607992452 hasConceptScore W1607992452C170493617 @default.
- W1607992452 hasConceptScore W1607992452C170734499 @default.
- W1607992452 hasConceptScore W1607992452C189206191 @default.
- W1607992452 hasConceptScore W1607992452C192772702 @default.
- W1607992452 hasConceptScore W1607992452C197077220 @default.
- W1607992452 hasConceptScore W1607992452C41008148 @default.
- W1607992452 hasConceptScore W1607992452C47701112 @default.
- W1607992452 hasConceptScore W1607992452C54355233 @default.
- W1607992452 hasConceptScore W1607992452C55493867 @default.
- W1607992452 hasConceptScore W1607992452C60644358 @default.
- W1607992452 hasConceptScore W1607992452C70721500 @default.
- W1607992452 hasConceptScore W1607992452C74187038 @default.
- W1607992452 hasConceptScore W1607992452C86803240 @default.
- W1607992452 hasIssue "10" @default.
- W1607992452 hasLocation W16079924521 @default.
- W1607992452 hasOpenAccess W1607992452 @default.
- W1607992452 hasPrimaryLocation W16079924521 @default.
- W1607992452 hasRelatedWork W1587822751 @default.
- W1607992452 hasRelatedWork W1973436781 @default.
- W1607992452 hasRelatedWork W1995100036 @default.
- W1607992452 hasRelatedWork W1995288338 @default.
- W1607992452 hasRelatedWork W1999779721 @default.
- W1607992452 hasRelatedWork W2024631466 @default.
- W1607992452 hasRelatedWork W2031966640 @default.
- W1607992452 hasRelatedWork W2061685714 @default.
- W1607992452 hasRelatedWork W2062068359 @default.
- W1607992452 hasRelatedWork W2125655246 @default.
- W1607992452 hasRelatedWork W2136616472 @default.
- W1607992452 hasRelatedWork W2144477832 @default.
- W1607992452 hasRelatedWork W2147932348 @default.
- W1607992452 hasRelatedWork W2180389172 @default.
- W1607992452 hasRelatedWork W2419340920 @default.
- W1607992452 hasRelatedWork W2768778425 @default.
- W1607992452 hasRelatedWork W2949354383 @default.
- W1607992452 hasRelatedWork W2952785685 @default.
- W1607992452 hasRelatedWork W3013848518 @default.
- W1607992452 hasRelatedWork W3092330864 @default.
- W1607992452 hasVolume "10" @default.
- W1607992452 isParatext "false" @default.
- W1607992452 isRetracted "false" @default.
- W1607992452 magId "1607992452" @default.
- W1607992452 workType "article" @default.