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- W1608053563 abstract "Lymphadenectomy is required in patients with high risk endometrial cancer which is defined as tumors with grade 3 differentiation, > 50% myometrial invasion, cervical invasion and/or clear cell or serous papillary histological subtype. The aim of this study was to develop and compare the performance of ultrasound based mathematical models to predict these high risk endometrial cancers. Women with endometrial cancer were prospectively scanned by experienced ultrasound examiners following a standardized protocol using 2D and 3D gray-scale and color Doppler imaging. Patients with the preoperative diagnosis of a non-endometrioid histotype or a grade 3 tumor were excluded because they were automatically referred for lymphadenectomy. Two logistic regression models were developed, one “objective” model using only the objective variables analyzed, and one “subjective” model using only subjective assessment of myometrial and cervical invasion, preoperative grading and demographic variables. One hundred forty-four women were included. Nineteen patients were excluded because no information on preoperative grading was available, 20 because they had a preoperative grade 3 tumor and 11 because the preoperative biopsy revealed a non-endometrioid histological subtype. In the remaining 94 patients, 57 (61%) had a stage IA tumor on final histology and 37 (39%) a stage IB or more. The “objective” model retained pre-operative grading and minimal free myometrium as variables and obtained an AUC of 0.76 (95% CI, 0.66 to 0.86). The “subjective” model retained pre-operative grading and subjective assessment of myometrial invasion and obtained an AUC of 0.78 (95% CI, 0.68 to 0.87). Comparison between the two models showed no difference in AUC: P-value 0.64. Both objective and subjective model predicted the high risk endometrial cancers with reasonable accuracy. After external validation they might be helpful for pre-operative triaging of patients with endometrioid cancer." @default.
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- W1608053563 date "2011-09-14" @default.
- W1608053563 modified "2023-10-03" @default.
- W1608053563 title "OC17.02: New ultrasound based mathematical models for the preoperative prediction of high risk endometrial cancer" @default.
- W1608053563 doi "https://doi.org/10.1002/uog.9185" @default.
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