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• W1608133052 endingPage "33" @default.
• W1608133052 startingPage "23" @default.
• W1608133052 abstract "Abstract Brain microdialysis has become a frequently used method to study the extracellular concentrations of neurotransmitters in specific areas of the brain. For years, and this is still the case today, dialysate concentrations and hence extracellular concentrations of neurotransmitters have been interpreted as a direct index of the neuronal release of these specific neurotransmitter systems. Although this seems to be the case for neurotransmitters such as dopamine, serotonin and acetylcholine, the extracellular concentrations of glutamate and GABA do not provide a reliable index of their synaptic exocytotic release. However, many microdialysis studies show changes in extracellular concentrations of glutamate and GABA under specific pharmacological and behavioural stimuli that could be interpreted as a consequence of the activation of specific neurochemical circuits. Despite this, we still do not know the origin and physiological significance of these changes of glutamate and GABA in the extracellular space. Here we propose that the changes in dialysate concentrations of these two neurotransmitters found under specific treatments could be an expression of the activity of the neurone–astrocyte unit in specific circuits of the brain. It is further proposed that dialysate changes of glutamate and GABA could be used as an index of volume transmission mediated actions of these two neurotransmitters in the brain. This hypothesis is based firstly on the assumption that the activity of neurones is functionally linked to the activity of astrocytes, which can release glutamate and GABA to the extracellular space; secondly, on the existence of extrasynaptic glutamate and GABA receptors with functional properties different from those of GABA receptors located at the synapse; and thirdly, on the experimental evidence reporting specific electrophysiological and neurochemical effects of glutamate and GABA when their levels are increased in the extracellular space. According to this concept, glutamate and GABA, once released into the extracellular compartment, could diffuse and have long‐lasting effects modulating glutamatergic and/or GABAergic neurone‐astrocytic networks and their interactions with other neurotransmitter neurone networks in the same areas of the brain." @default.
• W1608133052 created "2016-06-24" @default.
• W1608133052 creator A5003344696 @default.
• W1608133052 creator A5048458525 @default.
• W1608133052 creator A5056030840 @default.
• W1608133052 creator A5088480770 @default.
• W1608133052 date "2003-03-06" @default.
• W1608133052 modified "2023-10-16" @default.
• W1608133052 title "Changes in dialysate concentrations of glutamate and GABA in the brain: an index of volume transmission mediated actions?" @default.
• W1608133052 cites W113694765 @default.
• W1608133052 cites W1528717663 @default.
• W1608133052 cites W1533091812 @default.
• W1608133052 cites W1535641516 @default.
• W1608133052 cites W1537403132 @default.
• W1608133052 cites W1583493392 @default.
• W1608133052 cites W1600549717 @default.
• W1608133052 cites W1677920611 @default.
• W1608133052 cites W1884366104 @default.
• W1608133052 cites W1897919376 @default.
• W1608133052 cites W1902584234 @default.
• W1608133052 cites W1914381346 @default.
• W1608133052 cites W1921693572 @default.
• W1608133052 cites W1965792012 @default.
• W1608133052 cites W1967192722 @default.
• W1608133052 cites W1968669125 @default.
• W1608133052 cites W1968920506 @default.
• W1608133052 cites W1972212598 @default.
• W1608133052 cites W1973150811 @default.
• W1608133052 cites W1974273677 @default.
• W1608133052 cites W1977976400 @default.
• W1608133052 cites W1979948882 @default.
• W1608133052 cites W1980016842 @default.
• W1608133052 cites W1980590101 @default.
• W1608133052 cites W1981102082 @default.
• W1608133052 cites W1988622967 @default.
• W1608133052 cites W1988836643 @default.
• W1608133052 cites W1988900265 @default.
• W1608133052 cites W1989422254 @default.
• W1608133052 cites W1990449778 @default.
• W1608133052 cites W1993861337 @default.
• W1608133052 cites W1995827569 @default.
• W1608133052 cites W1999830007 @default.
• W1608133052 cites W2001537648 @default.
• W1608133052 cites W2003403901 @default.
• W1608133052 cites W2003801881 @default.
• W1608133052 cites W2004534434 @default.
• W1608133052 cites W2004937932 @default.
• W1608133052 cites W2005288574 @default.
• W1608133052 cites W2008524165 @default.
• W1608133052 cites W2008744095 @default.
• W1608133052 cites W2009190178 @default.
• W1608133052 cites W2012927321 @default.
• W1608133052 cites W2014615628 @default.
• W1608133052 cites W2015179821 @default.
• W1608133052 cites W2016153052 @default.
• W1608133052 cites W2020537971 @default.
• W1608133052 cites W2022233762 @default.
• W1608133052 cites W2024413181 @default.
• W1608133052 cites W2024919323 @default.
• W1608133052 cites W2035284119 @default.
• W1608133052 cites W2036838450 @default.
• W1608133052 cites W2041591122 @default.
• W1608133052 cites W2043440196 @default.
• W1608133052 cites W2044730840 @default.
• W1608133052 cites W2046603635 @default.
• W1608133052 cites W2050452462 @default.
• W1608133052 cites W2053739364 @default.
• W1608133052 cites W2056839574 @default.
• W1608133052 cites W2058107876 @default.
• W1608133052 cites W2061506085 @default.
• W1608133052 cites W2066562577 @default.
• W1608133052 cites W2068457237 @default.
• W1608133052 cites W2071984286 @default.
• W1608133052 cites W2074010758 @default.
• W1608133052 cites W2074217816 @default.
• W1608133052 cites W2078043304 @default.
• W1608133052 cites W2078586203 @default.
• W1608133052 cites W2080034700 @default.
• W1608133052 cites W2080288068 @default.
• W1608133052 cites W2084760609 @default.
• W1608133052 cites W2088445755 @default.
• W1608133052 cites W2089703628 @default.
• W1608133052 cites W2091155140 @default.
• W1608133052 cites W2091199294 @default.
• W1608133052 cites W2110119927 @default.
• W1608133052 cites W2113957975 @default.
• W1608133052 cites W2114116729 @default.
• W1608133052 cites W2130607773 @default.
• W1608133052 cites W2135382901 @default.
• W1608133052 cites W2143252669 @default.
• W1608133052 cites W2155644915 @default.
• W1608133052 cites W2156130516 @default.
• W1608133052 cites W2156381078 @default.
• W1608133052 cites W2160282214 @default.
• W1608133052 cites W2184424424 @default.
• W1608133052 cites W2247356410 @default.
• W1608133052 cites W2397119970 @default.
• W1608133052 cites W2408807018 @default.

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