Matches in SemOpenAlex for { <https://semopenalex.org/work/W1608293413> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1608293413 endingPage "555" @default.
- W1608293413 startingPage "548" @default.
- W1608293413 abstract "To investigate the role of cAMP-dependent protein kinase (PKA) and cAMP levels in ATP-dependent mitogenesis, Swiss 3T3 cells were transfected with an expression vector coding for (i) a mutated regulatory subunit of PKA (PKA mutant) or (ii) a yeast low Km cAMP phosphodiesterase gene (PDE mutant). The PKA mutant showed 70% reduced PKA activity. Phosphodiesterase activity increased 2.5-fold in the PDE mutant, leading to a great reduction of cAMP levels stimulated by ATP and other cAMP-increasing agents. The mitogenic responses of PKA and PDE mutants to insulin, epidermal growth factor, or 12-O-tetradecanoylphorbol-13-acetate were not significantly changed. However, the further stimulation by ATP, ADP, and adenosine 5'-(beta,gamma-imido)triphosphate in the presence of these growth factors was reduced by > 80%. Mitogenic effect of prostaglandin E2, forskolin, cholera toxin, or adenosine was inhibited in both mutants. The mitogenic stimulation by dibutyryl cAMP, which is resistant to phosphodiesterase, was inhibited in the PKA mutant, but not in the PDE mutant. A partial reduction of platelet-derived growth factor- or bombesin-stimulated mitogenesis, which involves protein kinase C as well as the cAMP signal, was observed in the mutants. These genetic results confirm pharmacological data on the role of PKA and cAMP levels in mitogenesis due to ATP and other growth factors." @default.
- W1608293413 created "2016-06-24" @default.
- W1608293413 creator A5029011859 @default.
- W1608293413 creator A5039975974 @default.
- W1608293413 creator A5046444950 @default.
- W1608293413 date "1994-01-01" @default.
- W1608293413 modified "2023-09-27" @default.
- W1608293413 title "Role of adenosine 3‘:5‘-monophosphate-dependent protein kinase and cAMP levels in ATP-dependent mitogenesis in Swiss 3T3 cells." @default.
- W1608293413 cites W116672086 @default.
- W1608293413 cites W1495653195 @default.
- W1608293413 cites W1505418565 @default.
- W1608293413 cites W1550813715 @default.
- W1608293413 cites W1552975638 @default.
- W1608293413 cites W155723902 @default.
- W1608293413 cites W1589735741 @default.
- W1608293413 cites W1602862920 @default.
- W1608293413 cites W1604810457 @default.
- W1608293413 cites W1928783644 @default.
- W1608293413 cites W1972420511 @default.
- W1608293413 cites W1982477399 @default.
- W1608293413 cites W1992472345 @default.
- W1608293413 cites W2010873815 @default.
- W1608293413 cites W2017235030 @default.
- W1608293413 cites W2023838194 @default.
- W1608293413 cites W2026777257 @default.
- W1608293413 cites W2027892263 @default.
- W1608293413 cites W2028028333 @default.
- W1608293413 cites W2031588343 @default.
- W1608293413 cites W2038576342 @default.
- W1608293413 cites W2047870205 @default.
- W1608293413 cites W2048812496 @default.
- W1608293413 cites W2052295727 @default.
- W1608293413 cites W2058486668 @default.
- W1608293413 cites W2068551128 @default.
- W1608293413 cites W2092424199 @default.
- W1608293413 cites W2092487107 @default.
- W1608293413 cites W2095442155 @default.
- W1608293413 cites W2095695875 @default.
- W1608293413 cites W2113208052 @default.
- W1608293413 cites W2118445198 @default.
- W1608293413 cites W2141088577 @default.
- W1608293413 cites W2148624765 @default.
- W1608293413 doi "https://doi.org/10.1016/s0021-9258(17)42384-2" @default.
- W1608293413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8276849" @default.
- W1608293413 hasPublicationYear "1994" @default.
- W1608293413 type Work @default.
- W1608293413 sameAs 1608293413 @default.
- W1608293413 citedByCount "21" @default.
- W1608293413 crossrefType "journal-article" @default.
- W1608293413 hasAuthorship W1608293413A5029011859 @default.
- W1608293413 hasAuthorship W1608293413A5039975974 @default.
- W1608293413 hasAuthorship W1608293413A5046444950 @default.
- W1608293413 hasBestOaLocation W16082934131 @default.
- W1608293413 hasConcept C104317684 @default.
- W1608293413 hasConcept C184235292 @default.
- W1608293413 hasConcept C185592680 @default.
- W1608293413 hasConcept C2776746612 @default.
- W1608293413 hasConcept C2776991684 @default.
- W1608293413 hasConcept C2779564974 @default.
- W1608293413 hasConcept C2779876172 @default.
- W1608293413 hasConcept C54009773 @default.
- W1608293413 hasConcept C55493867 @default.
- W1608293413 hasConcept C86803240 @default.
- W1608293413 hasConcept C95444343 @default.
- W1608293413 hasConcept C97029542 @default.
- W1608293413 hasConceptScore W1608293413C104317684 @default.
- W1608293413 hasConceptScore W1608293413C184235292 @default.
- W1608293413 hasConceptScore W1608293413C185592680 @default.
- W1608293413 hasConceptScore W1608293413C2776746612 @default.
- W1608293413 hasConceptScore W1608293413C2776991684 @default.
- W1608293413 hasConceptScore W1608293413C2779564974 @default.
- W1608293413 hasConceptScore W1608293413C2779876172 @default.
- W1608293413 hasConceptScore W1608293413C54009773 @default.
- W1608293413 hasConceptScore W1608293413C55493867 @default.
- W1608293413 hasConceptScore W1608293413C86803240 @default.
- W1608293413 hasConceptScore W1608293413C95444343 @default.
- W1608293413 hasConceptScore W1608293413C97029542 @default.
- W1608293413 hasIssue "1" @default.
- W1608293413 hasLocation W16082934131 @default.
- W1608293413 hasOpenAccess W1608293413 @default.
- W1608293413 hasPrimaryLocation W16082934131 @default.
- W1608293413 hasRelatedWork W1965802717 @default.
- W1608293413 hasRelatedWork W2010554332 @default.
- W1608293413 hasRelatedWork W2013216313 @default.
- W1608293413 hasRelatedWork W2019005882 @default.
- W1608293413 hasRelatedWork W2051850045 @default.
- W1608293413 hasRelatedWork W2070732778 @default.
- W1608293413 hasRelatedWork W2162798051 @default.
- W1608293413 hasRelatedWork W2414443002 @default.
- W1608293413 hasRelatedWork W2780603443 @default.
- W1608293413 hasRelatedWork W3186284413 @default.
- W1608293413 hasVolume "269" @default.
- W1608293413 isParatext "false" @default.
- W1608293413 isRetracted "false" @default.
- W1608293413 magId "1608293413" @default.
- W1608293413 workType "article" @default.