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- W160832675 abstract "Almost 2,000 years ago, Claudius Galen, the Greek physician and writer, proposed that the mental status of an individual may significantly influence one’s susceptibility to disease.1 This postulate serves as an historic landmark in the rapidly growing field of neuroendocrinimmunology, which was established through the recognition that the nervous, endocrine and immune systems control each other through bidirectional channels of communication, that employ both similar signals and receptors.2–7 At present, over 50 neurotransmitters, hormones and secretagogues are known that exert a profound impact on cellular, humoral and mucosal immunity.2–7 However, the exact nature of these interactions is extremely dependent upon the specific signal, target cell, and local microenvironment.8 Thus, depending upon the tissue, neuroendocrine action may result in stimulation, inhibition, or no effect, on immune expression.8 As an additional consideration, antigenic exposure to the immune system may lead to the generation of numerous lymphocytic cytokines (e.g. lymphokines, neuropeptides, hormones), that directly regulate neural and endocrine function.2–7 In consequence, an extensive, triangular interrelationship exists among the neural, endocrine and immune systems that acts to promote homeostasis and health." @default.
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- W160832675 date "1994-01-01" @default.
- W160832675 modified "2023-10-18" @default.
- W160832675 title "Androgen-Induced Suppression of Autoimmune Disease in Lacrimal Glands of Mouse Models of Sjögren’s Syndrome" @default.
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- W160832675 doi "https://doi.org/10.1007/978-1-4615-2417-5_115" @default.
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