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- W1608390601 startingPage "1857" @default.
- W1608390601 abstract "Differential scanning calorimetry was carried out to elucidate the properties of two metastable forms of chloramphenicol palmitate (δ form and sub-α form) and the occurrence and the role of the sub-α form during manufacturing of chloramphenicol palmitate oral suspension. The δ form, a new form, was obtained when the small amount of melted chloramphenicol palmitate was cooled very rapidly to below 0° and it was converted to the sub-α form at 23° on heating. The X-ray diffraction pattern of the δ form was distinguished from that of any other forms reported. The other form, sub-α, was obtained by warming the δ form or directly from the melt by rapid cooling. It was transformed to the α form while liberating heat from about 40° through about 75°. The X-ray diffraction pattern, infrared absorption spectra, the behavior in the hot stage of the polarizing microscope and the differential scanning calorimetric curves suggested that the sub-α form is composed of the crystallites of the α form. Estimated thermodynamic values at the 95% confidence limit were ; ΔHmelt→sub-α=-9.2±0.2kcal/mole, ΔHmelt→δ=-2.8±0.5 kcal/mole, ΔHδ→sub-a=-2.2±0.7 kcal/mole, and ΔHsub-α→α=-2.0±0.3 (the sub-α form directly form the melt) and -6.1±0.9 kcal/mole (the sub-α form via the δ form). The supercooled dispersion of chloramphenicol palmitate in the emulsifier solution turned into the suspension while stirring. The first solid state of the chloramphenicol palmitate was estimated to be the sub-α form and it was transformed to the α-form gradually." @default.
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- W1608390601 date "1973-01-01" @default.
- W1608390601 modified "2023-10-16" @default.
- W1608390601 title "Differential Scanning Calorimetry of Chloramphenicol Palmitate and the Phase-Transitional Behavior of Chloramphenicol Palmitate observed during the Preparation of Its Oral Suspension" @default.
- W1608390601 doi "https://doi.org/10.1248/cpb.21.1857" @default.
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