FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1608475035> ?p ?o ?g. }

• W1608475035 endingPage "371" @default.
• W1608475035 startingPage "364" @default.
• W1608475035 abstract "Summary Severe pneumonia is found in simultaneous influenza pneumonia and bacterial infection, and suggests a relationship with immunological mechanisms. Here, we performed two-dimensional gel electrophoresis to detect immunological molecules related to the fulminant pneumonia caused by influenza virus and Streptococcus pneumoniae co-infection in mice. We found two spots that were expressed strongly in co-infected mouse lungs, compared with S. pneumoniae or influenza virus singly infected mouse lungs. The spots were analysed by mass spectrometry, and identified as alpha-1 anti-trypsin (A1AT), known as an anti-protease for neutrophil-derived proteolytic enzymes, and creatine kinase, which reflects a greater degree of lung damage and cell death. A1AT expression was increased significantly, and proteolytic enzymes from neutrophils, such as neutrophil elastase, myeloperoxidase and lysozyme, were also secreted abundantly in influenza virus and S. pneumoniae co-infected lungs compared with S. pneumoniae or influenza virus singly infected lungs. These data suggest that A1AT may play a central role as a molecule with broad anti-inflammatory properties, and regulation of the neutrophil-mediated severe lung inflammation is important in the pathogenesis of co-infection with influenza virus and bacteria." @default.
• W1608475035 created "2016-06-24" @default.
• W1608475035 creator A5001766958 @default.
• W1608475035 creator A5002996271 @default.
• W1608475035 creator A5006757027 @default.
• W1608475035 creator A5033241128 @default.
• W1608475035 creator A5035464934 @default.
• W1608475035 creator A5044497202 @default.
• W1608475035 creator A5069266409 @default.
• W1608475035 creator A5086116258 @default.
• W1608475035 creator A5086299069 @default.
• W1608475035 creator A5086431156 @default.
• W1608475035 creator A5087903422 @default.
• W1608475035 date "2008-03-13" @default.
• W1608475035 modified "2023-10-16" @default.
• W1608475035 title "Two-dimensional gel electrophoresis analysis in simultaneous influenza pneumonia and bacterial infection in mice" @default.
• W1608475035 cites W1485417326 @default.
• W1608475035 cites W1558753212 @default.
• W1608475035 cites W1850898240 @default.
• W1608475035 cites W1978982224 @default.
• W1608475035 cites W1995362868 @default.
• W1608475035 cites W2014912901 @default.
• W1608475035 cites W2023967578 @default.
• W1608475035 cites W2043927300 @default.
• W1608475035 cites W2068287917 @default.
• W1608475035 cites W2075929424 @default.
• W1608475035 cites W2094312348 @default.
• W1608475035 cites W2107932739 @default.
• W1608475035 cites W2109254089 @default.
• W1608475035 cites W2110762664 @default.
• W1608475035 cites W2126262661 @default.
• W1608475035 cites W2131970256 @default.
• W1608475035 cites W2133979383 @default.
• W1608475035 cites W2135909713 @default.
• W1608475035 cites W2145665328 @default.
• W1608475035 cites W2153526281 @default.
• W1608475035 cites W2154443639 @default.
• W1608475035 cites W2169998037 @default.
• W1608475035 cites W2170960160 @default.
• W1608475035 cites W2284379072 @default.
• W1608475035 cites W2404496729 @default.
• W1608475035 cites W4213271223 @default.
• W1608475035 cites W4297919746 @default.
• W1608475035 doi "https://doi.org/10.1111/j.1365-2249.2008.03631.x" @default.
• W1608475035 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2384112" @default.
• W1608475035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18341613" @default.
• W1608475035 hasPublicationYear "2008" @default.
• W1608475035 type Work @default.
• W1608475035 sameAs 1608475035 @default.
• W1608475035 citedByCount "13" @default.
• W1608475035 countsByYear W16084750352012 @default.
• W1608475035 countsByYear W16084750352013 @default.
• W1608475035 countsByYear W16084750352014 @default.
• W1608475035 countsByYear W16084750352015 @default.
• W1608475035 countsByYear W16084750352017 @default.
• W1608475035 crossrefType "journal-article" @default.
• W1608475035 hasAuthorship W1608475035A5001766958 @default.
• W1608475035 hasAuthorship W1608475035A5002996271 @default.
• W1608475035 hasAuthorship W1608475035A5006757027 @default.
• W1608475035 hasAuthorship W1608475035A5033241128 @default.
• W1608475035 hasAuthorship W1608475035A5035464934 @default.
• W1608475035 hasAuthorship W1608475035A5044497202 @default.
• W1608475035 hasAuthorship W1608475035A5069266409 @default.
• W1608475035 hasAuthorship W1608475035A5086116258 @default.
• W1608475035 hasAuthorship W1608475035A5086299069 @default.
• W1608475035 hasAuthorship W1608475035A5086431156 @default.
• W1608475035 hasAuthorship W1608475035A5087903422 @default.
• W1608475035 hasBestOaLocation W16084750352 @default.
• W1608475035 hasConcept C126322002 @default.
• W1608475035 hasConcept C159047783 @default.
• W1608475035 hasConcept C181199279 @default.
• W1608475035 hasConcept C203014093 @default.
• W1608475035 hasConcept C203565725 @default.
• W1608475035 hasConcept C2522874641 @default.
• W1608475035 hasConcept C2776460866 @default.
• W1608475035 hasConcept C2776914184 @default.
• W1608475035 hasConcept C2777546802 @default.
• W1608475035 hasConcept C2777714996 @default.
• W1608475035 hasConcept C2777914695 @default.
• W1608475035 hasConcept C2781044401 @default.
• W1608475035 hasConcept C2781253189 @default.
• W1608475035 hasConcept C2781416681 @default.
• W1608475035 hasConcept C3019223276 @default.
• W1608475035 hasConcept C501593827 @default.
• W1608475035 hasConcept C55493867 @default.
• W1608475035 hasConcept C71924100 @default.
• W1608475035 hasConcept C86803240 @default.
• W1608475035 hasConcept C89423630 @default.
• W1608475035 hasConceptScore W1608475035C126322002 @default.
• W1608475035 hasConceptScore W1608475035C159047783 @default.
• W1608475035 hasConceptScore W1608475035C181199279 @default.
• W1608475035 hasConceptScore W1608475035C203014093 @default.
• W1608475035 hasConceptScore W1608475035C203565725 @default.
• W1608475035 hasConceptScore W1608475035C2522874641 @default.
• W1608475035 hasConceptScore W1608475035C2776460866 @default.
• W1608475035 hasConceptScore W1608475035C2776914184 @default.
• W1608475035 hasConceptScore W1608475035C2777546802 @default.
• W1608475035 hasConceptScore W1608475035C2777714996 @default.

• next