FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1608569838> ?p ?o ?g. }

• W1608569838 endingPage "6177" @default.
• W1608569838 startingPage "6166" @default.
• W1608569838 abstract "Abstract The effects of glucagon, epinephrine, and isoproterenol on adenosine 3',5'-monophosphate (cyclic AMP) accumulation and glucose mobilization have been studied in isolated rat livers perfused with Krebs bicarbonate buffer containing bovine erythrocytes and serum albumin. Glucagon and epinephrine produced detectable increases in liver cyclic AMP within 30 sec. With glucagon, the level of cyclic AMP rose to a maximum at 3 min and declined slowly over 1 hour. With epinephrine, the cyclic AMP concentration rapidly rose to a peak value at 1 min then declined to a lower level at 5 min and remained constant for the next 30 min. With maximally effective doses of glucagon, the cyclic AMP level was increased 11-fold at 1 min and 60-fold at 5 min. The corresponding values for epinephrine were only 4-fold and 2-fold. The lowest concentration of glucagon producing a significant elevation of cyclic AMP within 4 min was 2 x 10-10 m. A half-maximal cyclic AMP level was observed with about 1 x 10-8 m hormone. The minimally effective concentration of epinephrine for promotion of cyclic AMP accumulation was not clearly defined. A half-maximal response was observed with 1 x 10-7m hormone. By measuring changes in the glucose concentration of the effluent medium from livers from fed rats perfused without recirculation, it was possible to measure amounts of glucagon as low as 5 pmoles. The minimal concentration of glucagon producing significant glucose mobilization in the liver was 2 x 10-10 m while that of epinephrine was 1.4 x 10-8 m. These levels are similar to the minimal concentrations promoting adenosine 3',5'-monophosphate accumulation. Half-maximal glucose mobilization was observed with about 1 x 10-9 m glucagon or 1 x 10-7 m epinephrine. Norepinephrine and isoproterenol increased cyclic AMP accumulation and glucose output in livers perfused without recirculation. They were slightly less potent than epinephrine. Isoproterenol was much less potent than epinephrine or norepinephrine in stimulating glycogenolysis and gluconeogenesis in livers perfused with recirculating medium. Theophylline potentiated the effects of glucagon and epinephrine on cyclic AMP accumulation and glycogenolysis in the liver, whereas caffeine was ineffective. Serotonin, pancreozymin, and secretin did not affect glucose mobilization in livers from fed rats. Prostaglandin E1 and nicotinic acid did not alter basal or hormone-stimulated glucose production or cyclic AMP accumulation. Livers perfused with fluoride had reduced levels of cyclic AMP. Cessation of glucagon infusion resulted in a rapid fall in cyclic AMP levels, indicating rapid turnover of the nucleotide. When infusions of small amounts of glucagon, epinephrine, or cyclic AMP were stopped, glycogenolysis and gluconeogenesis declined at similar rates. The data are discussed in terms of the hypothesis that glucagon and catecholamines act in the liver by increasing the concentration of free, metabolically active cyclic AMP, and that this represents only a small fraction of the total tissue cyclic AMP." @default.
• W1608569838 created "2016-06-24" @default.
• W1608569838 creator A5017142632 @default.
• W1608569838 creator A5042494363 @default.
• W1608569838 creator A5060669543 @default.
• W1608569838 creator A5063926336 @default.
• W1608569838 date "1971-10-01" @default.
• W1608569838 modified "2023-10-06" @default.
• W1608569838 title "Studies on the Role of Adenosine 3',5'-Monophosphate in the Hepatic Actions of Glucagon and Catecholamines" @default.
• W1608569838 cites W1483105549 @default.
• W1608569838 cites W1488609485 @default.
• W1608569838 cites W1490796893 @default.
• W1608569838 cites W1510025470 @default.
• W1608569838 cites W1529705405 @default.
• W1608569838 cites W1546236203 @default.
• W1608569838 cites W1558093451 @default.
• W1608569838 cites W1561824493 @default.
• W1608569838 cites W1576399086 @default.
• W1608569838 cites W1578024134 @default.
• W1608569838 cites W1582996069 @default.
• W1608569838 cites W1588593248 @default.
• W1608569838 cites W1607650747 @default.
• W1608569838 cites W164778302 @default.
• W1608569838 cites W1657719861 @default.
• W1608569838 cites W1841822105 @default.
• W1608569838 cites W1863678882 @default.
• W1608569838 cites W1967028802 @default.
• W1608569838 cites W1969530315 @default.
• W1608569838 cites W1974960553 @default.
• W1608569838 cites W1975322235 @default.
• W1608569838 cites W1976510395 @default.
• W1608569838 cites W1981485116 @default.
• W1608569838 cites W1984619996 @default.
• W1608569838 cites W1995778527 @default.
• W1608569838 cites W1997062481 @default.
• W1608569838 cites W2000802462 @default.
• W1608569838 cites W2003776386 @default.
• W1608569838 cites W2004766516 @default.
• W1608569838 cites W2007270922 @default.
• W1608569838 cites W2017663351 @default.
• W1608569838 cites W2029484462 @default.
• W1608569838 cites W2030706656 @default.
• W1608569838 cites W2033355884 @default.
• W1608569838 cites W2043458856 @default.
• W1608569838 cites W2049708401 @default.
• W1608569838 cites W2067102849 @default.
• W1608569838 cites W2069440811 @default.
• W1608569838 cites W2075935248 @default.
• W1608569838 cites W2089693360 @default.
• W1608569838 cites W2091453166 @default.
• W1608569838 cites W2092107660 @default.
• W1608569838 cites W2103554213 @default.
• W1608569838 cites W2105056427 @default.
• W1608569838 cites W2112918293 @default.
• W1608569838 cites W2136016773 @default.
• W1608569838 cites W2150413431 @default.
• W1608569838 cites W2153660163 @default.
• W1608569838 cites W2159445989 @default.
• W1608569838 cites W2162687193 @default.
• W1608569838 cites W2218265958 @default.
• W1608569838 cites W2261378908 @default.
• W1608569838 cites W2413344347 @default.
• W1608569838 cites W60422700 @default.
• W1608569838 doi "https://doi.org/10.1016/s0021-9258(18)61771-5" @default.
• W1608569838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4331382" @default.
• W1608569838 hasPublicationYear "1971" @default.
• W1608569838 type Work @default.
• W1608569838 sameAs 1608569838 @default.
• W1608569838 citedByCount "296" @default.
• W1608569838 countsByYear W16085698382012 @default.
• W1608569838 countsByYear W16085698382014 @default.
• W1608569838 countsByYear W16085698382015 @default.
• W1608569838 countsByYear W16085698382016 @default.
• W1608569838 countsByYear W16085698382017 @default.
• W1608569838 countsByYear W16085698382018 @default.
• W1608569838 countsByYear W16085698382020 @default.
• W1608569838 countsByYear W16085698382021 @default.
• W1608569838 countsByYear W16085698382022 @default.
• W1608569838 countsByYear W16085698382023 @default.
• W1608569838 crossrefType "journal-article" @default.
• W1608569838 hasAuthorship W1608569838A5017142632 @default.
• W1608569838 hasAuthorship W1608569838A5042494363 @default.
• W1608569838 hasAuthorship W1608569838A5060669543 @default.
• W1608569838 hasAuthorship W1608569838A5063926336 @default.
• W1608569838 hasBestOaLocation W16085698381 @default.
• W1608569838 hasConcept C126322002 @default.
• W1608569838 hasConcept C134018914 @default.
• W1608569838 hasConcept C185592680 @default.
• W1608569838 hasConcept C2775859304 @default.
• W1608569838 hasConcept C2776991684 @default.
• W1608569838 hasConcept C2778563252 @default.
• W1608569838 hasConcept C2779876172 @default.
• W1608569838 hasConcept C71315377 @default.
• W1608569838 hasConcept C71924100 @default.
• W1608569838 hasConcept C86803240 @default.
• W1608569838 hasConceptScore W1608569838C126322002 @default.
• W1608569838 hasConceptScore W1608569838C134018914 @default.
• W1608569838 hasConceptScore W1608569838C185592680 @default.

• next