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- W160864982 abstract "Random isolation of exons from human chromosome 22 using the exon amplification procedure has identified a number of sequences having similarity to previously cloned genes. One exon was found to be highly similar to clathrin heavy chain genes. Previously, a putative clathrin heavy chain gene has been mapped to chromosome 17, but comparison of the predicted amino acid sequence of this gene to the other clathrin genes in public databases indicates that there is little or no similarity between the chromosome 17 gene and the others. The exon isolated from chromosome 22 shows significant similarity to the other clathrin genes but not the chromosome 17 sequence. This high level of peptide similarity extends even to the Drosophila melanogaster clathrin gene. Somatic cell hybrids containing different portions of chromosome 22 localize the gene above D22S193 placing it within the 22p12-q11 region, which is a particularly disease-rich region of the chromosome. A YAC and cosmid contig has been constructed surrounding the gene and isolation of a full-length cDNA is in progress. The localization of this gene is especially important given the role of clathrin with regards to receptor-mediated endocytosis and signal transduction." @default.
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- W160864982 date "1994-09-01" @default.
- W160864982 modified "2023-09-26" @default.
- W160864982 title "Localization of a clathrin heavy chain gene to chromosome 22" @default.
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