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• W1608668001 abstract "For over fifty years, people have used antibiotics to treat illnesses caused by pathogens. However, the excessive and inappropriate use of these antibiotics in clinical treatment of humans and animals has increased pathogen resistance to these compounds, turning them into less effective agents. There has also been an increase in the generation of multidrugresistant pathogens, primarily bacteria and fungi that resist the effects of most currently available antibiotics (Heuer et al., 2006; Field, 2010). Until now, the pharmaceutical industry is facing this problem by looking for new antibiotics or modifying existing ones. However, pathogens have proven to have the ability to quickly develop and disseminate resistance mechanisms, which compromises this strategy, becoming it less effective. This clearly shows the need to develop new biomedical treatments with different action mechanisms from those of conventional antibiotics (Parisien et al., 2008). This problem has led that efforts being made on research and development of new biomedical alternatives, among which antimicrobial peptides (AMPs) are considered one of the most promising options. AMPs are produced by a wide variety of organisms as part of their first line of defense (eukaryotes) or as a competition strategy for nutrients and space (prokaryotes). These molecules are usually short peptides (12-100 amino acid residues); have a positive charge (+2 to +9), although there are also neutral and negatively charged. They are amphipathic and have been isolated from bacteria, plants and animals, including humans; which give us an overview of the enormous structural diversity of these molecules and their different action mechanisms (Murray & Liu, 2008). The continuous discovery of new AMPs groups in diverse organisms has turned these natural antibiotics into the basic elements of a new generation of potential biomedical treatments against infectious diseases in humans and animals. Besides the above, the broad spectrum of biological activities reported for these molecules suggests a potential benefit in cancer treatment, viral and parasitic infections and in the modulation of the immune system, which reinforces the importance of studying these molecules (Mercado et al., 2005; Schweizer, 2009)." @default.
• W1608668001 created "2016-06-24" @default.
• W1608668001 creator A5006612244 @default.
• W1608668001 creator A5035415933 @default.
• W1608668001 creator A5075299662 @default.
• W1608668001 date "2011-01-08" @default.
• W1608668001 modified "2023-10-04" @default.
• W1608668001 title "Antimicrobial Peptides: Diversity and Perspectives for Their Biomedical Application" @default.
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