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- W1608693609 endingPage "493" @default.
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- W1608693609 abstract "Biological tissues/organs consist of hierarchical organization of various extracellular matrix (ECM) molecules with spatial arrangement of cells and soluble factors. Highly hydrated ECM molecules assemble to form fibrils, microfibrils that organize into regional tissue structures such as muscle fiber bundles or osteons, tightly adapted to the specific tissue functions. Tissue architecture also defines spatial organization of biochemical and mechanical cues, in turn creating highly complex and heterogeneous cellular microenvironments. To generate the functional tissue equivalents in vitro, engineered scaffolds should mimic the structural, mechanochemical, and cellular complexity by recapitulating the unique microenvironments observed during the tissue development and morphogenesis. Inspired by complex and heterogeneous biological organization and enabled by various microfabrication and nanofabrication techniques, microscale hydrogel blocks can be engineered with specific structural, mechanical, biochemical, and cellular cues and assembled with the hope of generating complex functional tissue analogs. In this chapter, we highlight the biological examples of heterogeneous, yet tissue-specific organization of the structural, mechanical, biochemical, and cellular components in the tissues/organs. We further summarize strategies to engineer the hydrogels with specific set of cues followed by the techniques to assemble the engineered hydrogels blocks to build complex tissue analogs." @default.
- W1608693609 created "2016-06-24" @default.
- W1608693609 creator A5029915129 @default.
- W1608693609 creator A5033056518 @default.
- W1608693609 creator A5059469425 @default.
- W1608693609 creator A5081499203 @default.
- W1608693609 creator A5087859572 @default.
- W1608693609 date "2012-10-24" @default.
- W1608693609 modified "2023-10-18" @default.
- W1608693609 title "Tissue Analogs by the Assembly of Engineered Hydrogel Blocks" @default.
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