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- W1608713034 endingPage "347" @default.
- W1608713034 startingPage "309" @default.
- W1608713034 abstract "Publisher Summary Although dopamine (DA) has long been implicated in the pathophysiology of schizophrenia, it has been clear for some time that malfunction in this neurotransmitter system is not sufficient of itself to account for all the clinical pathology. One of the major problems in schizophrenia research is the episodic nature of the illness. One must distinguish between findings present at all times in the schizophrenic individual (trait dependent) and those that are characteristic only of more symptomatic periods and may disappear interepisodically (state dependent). Most evidence supports a state-dependent disorder of DA dysregulation. There is also evidence for norepinephrine (NE)-related state-dependent changes. State dependency is not established as clearly for the serotonin (5HT) and GABA system but could be present; both of these interact with the DA and NE systems. This chapter discusses the evidence linking the nondopaminergic NE, 5HT, and GABA systems with schizophrenia and emphasizes those findings that have been replicated most frequently. It indicates the relationships with other systems, especially DA, and with clinical syndromes whenever possible. It also advances some concepts that may facilitate the understanding of these diverse and conflicting data, such as their relation to state dependency, clinical instability, stress sensitivity, relapse, and genetic vulnerability. The concept of a one-neurotransmitter system disorder in schizophrenia can no longer be sustained." @default.
- W1608713034 created "2016-06-24" @default.
- W1608713034 creator A5031213780 @default.
- W1608713034 creator A5044047568 @default.
- W1608713034 date "1988-01-01" @default.
- W1608713034 modified "2023-10-18" @default.
- W1608713034 title "Schizophrenia: Instability in Norepinephrine, Serotonin, and γ-Aminobutyric Acid Systems" @default.
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