Matches in SemOpenAlex for { <https://semopenalex.org/work/W1609131738> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1609131738 endingPage "7" @default.
- W1609131738 startingPage "2574" @default.
- W1609131738 abstract "The effect of diethyldithiocarbamate (DDTC) on myelotoxicity induced by 1,3-bis(2-chloroethyl)-1-nitrosourea, Adriamycin, or mitomycin C in C57BL/6J x DBA/2J mice is reported here. All drugs were administered i.v. Myelotoxicity was assessed, 24 h after administration of the myelotoxic drug, using bone marrow stem cell (spleen colony-forming unit) and granulocyte/macrophage progenitor cell (granulocyte/macrophage colony-forming unit in culture) clonogenic assays. Administration of DDTC alone had no effect on spleen colony-forming units or granulocyte/macrophage colony-forming units in culture. 1,3-Bis(2-chloroethyl)-1-nitrosourea showed a dose-dependent toxicity for both cell types, and subsequent treatment with DDTC (300 mg/kg i.v. 3 h after 1,3-bis(2-chloroethyl)-1-nitrosourea) ameliorated this toxicity. The same dosing regimen of DDTC ameliorated Adriamycin-induced toxicity to bone marrow stem cells at the two higher doses tested. However, the myelosuppressive effects of mitomycin C were not altered by DDTC administration (300 mg/kg i.v. 3 h after or 30 min before mitomycin C). These results demonstrate that DDTC ameliorates myelotoxicity induced by several, but not all, chemotherapeutic agents and suggest a broad role for DDTC in cancer chemotherapy." @default.
- W1609131738 created "2016-06-24" @default.
- W1609131738 creator A5024460894 @default.
- W1609131738 creator A5040900629 @default.
- W1609131738 date "1989-05-15" @default.
- W1609131738 modified "2023-09-23" @default.
- W1609131738 title "Myeloprotective effect of diethyldithiocarbamate treatment following 1,3-bis(2-chloroethyl)-1-nitrosourea, adriamycin, or mitomycin C in mice." @default.
- W1609131738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2540902" @default.
- W1609131738 hasPublicationYear "1989" @default.
- W1609131738 type Work @default.
- W1609131738 sameAs 1609131738 @default.
- W1609131738 citedByCount "3" @default.
- W1609131738 crossrefType "journal-article" @default.
- W1609131738 hasAuthorship W1609131738A5024460894 @default.
- W1609131738 hasAuthorship W1609131738A5040900629 @default.
- W1609131738 hasConcept C117262875 @default.
- W1609131738 hasConcept C126322002 @default.
- W1609131738 hasConcept C141071460 @default.
- W1609131738 hasConcept C185592680 @default.
- W1609131738 hasConcept C201750760 @default.
- W1609131738 hasConcept C202751555 @default.
- W1609131738 hasConcept C203014093 @default.
- W1609131738 hasConcept C2776694085 @default.
- W1609131738 hasConcept C2776755627 @default.
- W1609131738 hasConcept C2776946711 @default.
- W1609131738 hasConcept C2779338040 @default.
- W1609131738 hasConcept C2780007613 @default.
- W1609131738 hasConcept C2780147359 @default.
- W1609131738 hasConcept C2780931953 @default.
- W1609131738 hasConcept C28328180 @default.
- W1609131738 hasConcept C29730261 @default.
- W1609131738 hasConcept C54355233 @default.
- W1609131738 hasConcept C55493867 @default.
- W1609131738 hasConcept C71924100 @default.
- W1609131738 hasConcept C86803240 @default.
- W1609131738 hasConcept C98274493 @default.
- W1609131738 hasConceptScore W1609131738C117262875 @default.
- W1609131738 hasConceptScore W1609131738C126322002 @default.
- W1609131738 hasConceptScore W1609131738C141071460 @default.
- W1609131738 hasConceptScore W1609131738C185592680 @default.
- W1609131738 hasConceptScore W1609131738C201750760 @default.
- W1609131738 hasConceptScore W1609131738C202751555 @default.
- W1609131738 hasConceptScore W1609131738C203014093 @default.
- W1609131738 hasConceptScore W1609131738C2776694085 @default.
- W1609131738 hasConceptScore W1609131738C2776755627 @default.
- W1609131738 hasConceptScore W1609131738C2776946711 @default.
- W1609131738 hasConceptScore W1609131738C2779338040 @default.
- W1609131738 hasConceptScore W1609131738C2780007613 @default.
- W1609131738 hasConceptScore W1609131738C2780147359 @default.
- W1609131738 hasConceptScore W1609131738C2780931953 @default.
- W1609131738 hasConceptScore W1609131738C28328180 @default.
- W1609131738 hasConceptScore W1609131738C29730261 @default.
- W1609131738 hasConceptScore W1609131738C54355233 @default.
- W1609131738 hasConceptScore W1609131738C55493867 @default.
- W1609131738 hasConceptScore W1609131738C71924100 @default.
- W1609131738 hasConceptScore W1609131738C86803240 @default.
- W1609131738 hasConceptScore W1609131738C98274493 @default.
- W1609131738 hasIssue "10" @default.
- W1609131738 hasLocation W16091317381 @default.
- W1609131738 hasOpenAccess W1609131738 @default.
- W1609131738 hasPrimaryLocation W16091317381 @default.
- W1609131738 hasRelatedWork W1609131738 @default.
- W1609131738 hasRelatedWork W2038235266 @default.
- W1609131738 hasRelatedWork W2041729358 @default.
- W1609131738 hasRelatedWork W2052949270 @default.
- W1609131738 hasRelatedWork W2084871044 @default.
- W1609131738 hasRelatedWork W2269837704 @default.
- W1609131738 hasRelatedWork W2380891798 @default.
- W1609131738 hasRelatedWork W2426625857 @default.
- W1609131738 hasRelatedWork W2899084033 @default.
- W1609131738 hasRelatedWork W904724701 @default.
- W1609131738 hasVolume "49" @default.
- W1609131738 isParatext "false" @default.
- W1609131738 isRetracted "false" @default.
- W1609131738 magId "1609131738" @default.
- W1609131738 workType "article" @default.