Matches in SemOpenAlex for { <https://semopenalex.org/work/W16092433> ?p ?o ?g. }
- W16092433 endingPage "1286" @default.
- W16092433 startingPage "1195" @default.
- W16092433 abstract "The necessity for a close functional relationship between the male reproductive tract and the immune system is self-evident. Spermatogenic cells are particularly susceptible to immunological responses, and activation of immunity against sperm or other elements of the reproductive tract can lead to androgen insufficiency, infertility, or chronic inflammatory conditions. Inflammation and immune activation directly inhibit the hypothalamic–pituitary–Leydig cell axis, interfere with essential interactions between the Sertoli cells and spermatogenic cells, and increase the potential for sperm antibody formation, a major cause of infertility in men. It is fortunate, therefore, that spermatogenic cells normally are ignored by the immune system, as are grafts of foreign tissues placed within the testicular capsule. Traditional explanations for the protection of these cells, based on “immune privilege” of the testis maintained by the blood–testis barrier or by exclusion of immune cells, are not consistent with either the histological organization of the reproductive tract or modern concepts of immunoregulation. A more realistic understanding of the control of immune responses in the male reproductive tract should focus on the activity of immunoregulatory macrophages and lymphocytes, as well as active suppression of antigen-specific immunity by somatic cells involving regulatory cytokines, androgenic steroids, and other antiinflammatory and immunosuppressive factors. Equally important for maintaining fertility, it appears that the restraints on antigen-specific immunity in the male reproductive tract are counterbalanced by enhanced local innate immune mechanisms and conventional mucosal immunity. In the testis, at least, there is convincing evidence that establishment of reproductive function during development is linked to the normal development of the local immune environment." @default.
- W16092433 created "2016-06-24" @default.
- W16092433 creator A5016793878 @default.
- W16092433 creator A5022826774 @default.
- W16092433 date "2006-01-01" @default.
- W16092433 modified "2023-10-12" @default.
- W16092433 title "Immunophysiology of the Male Reproductive Tract" @default.
- W16092433 cites W101524103 @default.
- W16092433 cites W102409311 @default.
- W16092433 cites W115845800 @default.
- W16092433 cites W118722372 @default.
- W16092433 cites W121387658 @default.
- W16092433 cites W1215373674 @default.
- W16092433 cites W121950046 @default.
- W16092433 cites W139231867 @default.
- W16092433 cites W143493110 @default.
- W16092433 cites W1482096612 @default.
- W16092433 cites W1482689539 @default.
- W16092433 cites W1483485730 @default.
- W16092433 cites W1485665880 @default.
- W16092433 cites W1487018400 @default.
- W16092433 cites W1491413470 @default.
- W16092433 cites W1492642178 @default.
- W16092433 cites W1492839610 @default.
- W16092433 cites W1493553575 @default.
- W16092433 cites W1497187337 @default.
- W16092433 cites W1498088159 @default.
- W16092433 cites W1498282354 @default.
- W16092433 cites W1503981072 @default.
- W16092433 cites W1505010441 @default.
- W16092433 cites W1509255897 @default.
- W16092433 cites W1515326854 @default.
- W16092433 cites W1515719112 @default.
- W16092433 cites W1515725948 @default.
- W16092433 cites W1515994079 @default.
- W16092433 cites W1517426366 @default.
- W16092433 cites W1518896693 @default.
- W16092433 cites W1519673270 @default.
- W16092433 cites W1521031916 @default.
- W16092433 cites W1521279620 @default.
- W16092433 cites W1521938029 @default.
- W16092433 cites W1524123582 @default.
- W16092433 cites W1524963853 @default.
- W16092433 cites W1525310310 @default.
- W16092433 cites W1527997848 @default.
- W16092433 cites W1531742112 @default.
- W16092433 cites W1531903285 @default.
- W16092433 cites W1536322469 @default.
- W16092433 cites W1536523744 @default.
- W16092433 cites W1536609760 @default.
- W16092433 cites W1538323547 @default.
- W16092433 cites W1539392991 @default.
- W16092433 cites W1542568396 @default.
- W16092433 cites W1549886276 @default.
- W16092433 cites W1552885427 @default.
- W16092433 cites W1553342043 @default.
- W16092433 cites W1554518376 @default.
- W16092433 cites W1554527416 @default.
- W16092433 cites W1555311341 @default.
- W16092433 cites W1555988808 @default.
- W16092433 cites W1556867369 @default.
- W16092433 cites W1557480462 @default.
- W16092433 cites W1558372199 @default.
- W16092433 cites W1559200425 @default.
- W16092433 cites W1560571961 @default.
- W16092433 cites W1562208709 @default.
- W16092433 cites W1565755899 @default.
- W16092433 cites W1567420244 @default.
- W16092433 cites W1567652512 @default.
- W16092433 cites W1569282854 @default.
- W16092433 cites W1570367374 @default.
- W16092433 cites W1570517267 @default.
- W16092433 cites W1570888300 @default.
- W16092433 cites W157109511 @default.
- W16092433 cites W1572198832 @default.
- W16092433 cites W1572234645 @default.
- W16092433 cites W1573643687 @default.
- W16092433 cites W1574660876 @default.
- W16092433 cites W1575774937 @default.
- W16092433 cites W1576548155 @default.
- W16092433 cites W1580139289 @default.
- W16092433 cites W1580335466 @default.
- W16092433 cites W1583971934 @default.
- W16092433 cites W1586392520 @default.
- W16092433 cites W1587832347 @default.
- W16092433 cites W1589529996 @default.
- W16092433 cites W1589628861 @default.
- W16092433 cites W1589679215 @default.
- W16092433 cites W1590429086 @default.
- W16092433 cites W1591616590 @default.
- W16092433 cites W1593025965 @default.
- W16092433 cites W1594649446 @default.
- W16092433 cites W159478643 @default.
- W16092433 cites W1596292382 @default.
- W16092433 cites W1596872190 @default.
- W16092433 cites W1599776525 @default.
- W16092433 cites W1604105113 @default.
- W16092433 cites W1604984067 @default.