Matches in SemOpenAlex for { <https://semopenalex.org/work/W1609309938> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1609309938 endingPage "3964" @default.
- W1609309938 startingPage "3959" @default.
- W1609309938 abstract "We describe a 15-yr-old girl with recurrent bacterial infections who is refractory to the effects of LPS in vivo and in vitro and IL-1 in vitro. Intravenous challenge of the patient with Escherichia coli endotoxin caused a subnormal febrile response, little alteration in the number of circulating neutrophils, and subnormal elevations in the plasma levels of TNF-alpha, IL-6, IL-8, lactoferrin, and granulocyte CSF; however, normal levels of the anti-inflammatory mediators IL-1 receptor antagonist and soluble TNF receptor (60 kDa) were induced. Studies in vitro indicated the patient's monocytes expressed CD14, the LPS receptor, and bound LPS in a specific manner, but failed to produce TNF-alpha and granulocyte CSF after stimulation with LPS, and failed to respond to IL-1, heat-killed Staphylococcus aureus, and soluble glucan. Peripheral blood patient neutrophils exhibited normal expression of CD14, but failed to respond to treatment with LPS (100-1000 ng/ml for 30 min at 37 degrees C), a treatment that caused increased expression of the surface markers, C10, CD18, CD11b, CD67, and CD45, and decreased expression of L-selectin in normal neutrophils. Treatment of normal and patient neutrophils with FMLP (0.1 microM) resulted in equivalent altered expression of these surface markers. Patient neutrophils could not be primed by either LPS or IL-1beta for enhanced FMLP-induced O2- generation, but primed normally to TNF-alpha and platelet-activating factor. This patient's hyporesponsiveness to LPS and IL-1 is most likely due to a defect very early in the signal-transduction pathway." @default.
- W1609309938 created "2016-06-24" @default.
- W1609309938 creator A5018910683 @default.
- W1609309938 creator A5052952592 @default.
- W1609309938 creator A5091757859 @default.
- W1609309938 date "1997-04-15" @default.
- W1609309938 modified "2023-10-14" @default.
- W1609309938 title "Endotoxin and IL-1 hyporesponsiveness in a patient with recurrent bacterial infections." @default.
- W1609309938 doi "https://doi.org/10.4049/jimmunol.158.8.3959" @default.
- W1609309938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9103466" @default.
- W1609309938 hasPublicationYear "1997" @default.
- W1609309938 type Work @default.
- W1609309938 sameAs 1609309938 @default.
- W1609309938 citedByCount "68" @default.
- W1609309938 countsByYear W16093099382013 @default.
- W1609309938 countsByYear W16093099382014 @default.
- W1609309938 countsByYear W16093099382015 @default.
- W1609309938 countsByYear W16093099382019 @default.
- W1609309938 countsByYear W16093099382020 @default.
- W1609309938 countsByYear W16093099382023 @default.
- W1609309938 crossrefType "journal-article" @default.
- W1609309938 hasAuthorship W1609309938A5018910683 @default.
- W1609309938 hasAuthorship W1609309938A5052952592 @default.
- W1609309938 hasAuthorship W1609309938A5091757859 @default.
- W1609309938 hasBestOaLocation W16093099381 @default.
- W1609309938 hasConcept C114684123 @default.
- W1609309938 hasConcept C126322002 @default.
- W1609309938 hasConcept C134018914 @default.
- W1609309938 hasConcept C147483822 @default.
- W1609309938 hasConcept C150903083 @default.
- W1609309938 hasConcept C167672396 @default.
- W1609309938 hasConcept C170493617 @default.
- W1609309938 hasConcept C171779818 @default.
- W1609309938 hasConcept C17991360 @default.
- W1609309938 hasConcept C202751555 @default.
- W1609309938 hasConcept C203014093 @default.
- W1609309938 hasConcept C207001950 @default.
- W1609309938 hasConcept C2776885963 @default.
- W1609309938 hasConcept C2777983669 @default.
- W1609309938 hasConcept C2778122271 @default.
- W1609309938 hasConcept C2778513237 @default.
- W1609309938 hasConcept C2778754761 @default.
- W1609309938 hasConcept C2779170986 @default.
- W1609309938 hasConcept C2781462264 @default.
- W1609309938 hasConcept C2993002077 @default.
- W1609309938 hasConcept C55493867 @default.
- W1609309938 hasConcept C71924100 @default.
- W1609309938 hasConcept C86803240 @default.
- W1609309938 hasConceptScore W1609309938C114684123 @default.
- W1609309938 hasConceptScore W1609309938C126322002 @default.
- W1609309938 hasConceptScore W1609309938C134018914 @default.
- W1609309938 hasConceptScore W1609309938C147483822 @default.
- W1609309938 hasConceptScore W1609309938C150903083 @default.
- W1609309938 hasConceptScore W1609309938C167672396 @default.
- W1609309938 hasConceptScore W1609309938C170493617 @default.
- W1609309938 hasConceptScore W1609309938C171779818 @default.
- W1609309938 hasConceptScore W1609309938C17991360 @default.
- W1609309938 hasConceptScore W1609309938C202751555 @default.
- W1609309938 hasConceptScore W1609309938C203014093 @default.
- W1609309938 hasConceptScore W1609309938C207001950 @default.
- W1609309938 hasConceptScore W1609309938C2776885963 @default.
- W1609309938 hasConceptScore W1609309938C2777983669 @default.
- W1609309938 hasConceptScore W1609309938C2778122271 @default.
- W1609309938 hasConceptScore W1609309938C2778513237 @default.
- W1609309938 hasConceptScore W1609309938C2778754761 @default.
- W1609309938 hasConceptScore W1609309938C2779170986 @default.
- W1609309938 hasConceptScore W1609309938C2781462264 @default.
- W1609309938 hasConceptScore W1609309938C2993002077 @default.
- W1609309938 hasConceptScore W1609309938C55493867 @default.
- W1609309938 hasConceptScore W1609309938C71924100 @default.
- W1609309938 hasConceptScore W1609309938C86803240 @default.
- W1609309938 hasIssue "8" @default.
- W1609309938 hasLocation W16093099381 @default.
- W1609309938 hasLocation W16093099382 @default.
- W1609309938 hasOpenAccess W1609309938 @default.
- W1609309938 hasPrimaryLocation W16093099381 @default.
- W1609309938 hasRelatedWork W1609309938 @default.
- W1609309938 hasRelatedWork W1966981336 @default.
- W1609309938 hasRelatedWork W1978918614 @default.
- W1609309938 hasRelatedWork W2036447754 @default.
- W1609309938 hasRelatedWork W2052574312 @default.
- W1609309938 hasRelatedWork W2063619316 @default.
- W1609309938 hasRelatedWork W2094420336 @default.
- W1609309938 hasRelatedWork W2121247049 @default.
- W1609309938 hasRelatedWork W2141130289 @default.
- W1609309938 hasRelatedWork W2428826040 @default.
- W1609309938 hasVolume "158" @default.
- W1609309938 isParatext "false" @default.
- W1609309938 isRetracted "false" @default.
- W1609309938 magId "1609309938" @default.
- W1609309938 workType "article" @default.