Matches in SemOpenAlex for { <https://semopenalex.org/work/W1609376551> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1609376551 endingPage "91" @default.
- W1609376551 startingPage "685" @default.
- W1609376551 abstract "As part of a clinical research project, proliferative parameters were studied in primary breast cancer: standardization and technical validation of thymidine kinase (TK), thymidylate synthase (TS) and protein tyrosine kinase (PTK) are described. A total of 633 frozen tumor specimens, available in four institutions, was analyzed in three flow cytometry laboratories for DNA content and percentage of S-phase cells (%S) measurement. 1) The standardization step consisted in developing a common protocol for sample preparation; then, common cell suspensions were analyzed in order to perform an inter-laboratory control. Objective guidelines were elaborated to interpret DNA histograms in breast carcinoma. 2) DNA-aneuploidy was observed in 61% of cases of the retrospective series. Compared with DNA-aneuploid tumors, mean %S was significantly lower in case of DNA-diploidy (respectively: 6.4% and 2.2%, p < 0.001). When compared between the four institutions, %S distributions did not differ significantly. 3) %S is strongly correlated with TK, TS and PTK and high percentages were also observed in high grade tumors or tumor without hormone receptors. These results show that a standardization in using flow cytometers and DNA software allows multicenter studies." @default.
- W1609376551 created "2016-06-24" @default.
- W1609376551 creator A5021802521 @default.
- W1609376551 creator A5026604806 @default.
- W1609376551 creator A5043891942 @default.
- W1609376551 creator A5064835150 @default.
- W1609376551 creator A5071909609 @default.
- W1609376551 creator A5077311793 @default.
- W1609376551 creator A5079805601 @default.
- W1609376551 creator A5091747535 @default.
- W1609376551 date "1999-09-08" @default.
- W1609376551 modified "2023-10-15" @default.
- W1609376551 title "[Standardization and quality control in the evaluation of proliferation parameters in T1T2, N0N1, M0 breast cancer: multicentric retrospective study II. DNA-ploidy and S-phase fraction]." @default.
- W1609376551 cites W1974731601 @default.
- W1609376551 cites W1977379434 @default.
- W1609376551 cites W1983178647 @default.
- W1609376551 cites W1993320831 @default.
- W1609376551 cites W2018696261 @default.
- W1609376551 cites W2039976295 @default.
- W1609376551 cites W2055687655 @default.
- W1609376551 cites W2059507725 @default.
- W1609376551 cites W2070807241 @default.
- W1609376551 cites W2083072213 @default.
- W1609376551 cites W2087667466 @default.
- W1609376551 cites W2093960667 @default.
- W1609376551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10477386" @default.
- W1609376551 hasPublicationYear "1999" @default.
- W1609376551 type Work @default.
- W1609376551 sameAs 1609376551 @default.
- W1609376551 citedByCount "5" @default.
- W1609376551 countsByYear W16093765512012 @default.
- W1609376551 countsByYear W16093765512013 @default.
- W1609376551 countsByYear W16093765512017 @default.
- W1609376551 crossrefType "journal-article" @default.
- W1609376551 hasAuthorship W1609376551A5021802521 @default.
- W1609376551 hasAuthorship W1609376551A5026604806 @default.
- W1609376551 hasAuthorship W1609376551A5043891942 @default.
- W1609376551 hasAuthorship W1609376551A5064835150 @default.
- W1609376551 hasAuthorship W1609376551A5071909609 @default.
- W1609376551 hasAuthorship W1609376551A5077311793 @default.
- W1609376551 hasAuthorship W1609376551A5079805601 @default.
- W1609376551 hasAuthorship W1609376551A5091747535 @default.
- W1609376551 hasConcept C104317684 @default.
- W1609376551 hasConcept C111919701 @default.
- W1609376551 hasConcept C121608353 @default.
- W1609376551 hasConcept C126322002 @default.
- W1609376551 hasConcept C142724271 @default.
- W1609376551 hasConcept C143998085 @default.
- W1609376551 hasConcept C153911025 @default.
- W1609376551 hasConcept C188087704 @default.
- W1609376551 hasConcept C2779672484 @default.
- W1609376551 hasConcept C3018521938 @default.
- W1609376551 hasConcept C30481170 @default.
- W1609376551 hasConcept C41008148 @default.
- W1609376551 hasConcept C530470458 @default.
- W1609376551 hasConcept C54355233 @default.
- W1609376551 hasConcept C552990157 @default.
- W1609376551 hasConcept C553184892 @default.
- W1609376551 hasConcept C71924100 @default.
- W1609376551 hasConcept C86803240 @default.
- W1609376551 hasConceptScore W1609376551C104317684 @default.
- W1609376551 hasConceptScore W1609376551C111919701 @default.
- W1609376551 hasConceptScore W1609376551C121608353 @default.
- W1609376551 hasConceptScore W1609376551C126322002 @default.
- W1609376551 hasConceptScore W1609376551C142724271 @default.
- W1609376551 hasConceptScore W1609376551C143998085 @default.
- W1609376551 hasConceptScore W1609376551C153911025 @default.
- W1609376551 hasConceptScore W1609376551C188087704 @default.
- W1609376551 hasConceptScore W1609376551C2779672484 @default.
- W1609376551 hasConceptScore W1609376551C3018521938 @default.
- W1609376551 hasConceptScore W1609376551C30481170 @default.
- W1609376551 hasConceptScore W1609376551C41008148 @default.
- W1609376551 hasConceptScore W1609376551C530470458 @default.
- W1609376551 hasConceptScore W1609376551C54355233 @default.
- W1609376551 hasConceptScore W1609376551C552990157 @default.
- W1609376551 hasConceptScore W1609376551C553184892 @default.
- W1609376551 hasConceptScore W1609376551C71924100 @default.
- W1609376551 hasConceptScore W1609376551C86803240 @default.
- W1609376551 hasIssue "7-8" @default.
- W1609376551 hasLocation W16093765511 @default.
- W1609376551 hasOpenAccess W1609376551 @default.
- W1609376551 hasPrimaryLocation W16093765511 @default.
- W1609376551 hasRelatedWork W1975273638 @default.
- W1609376551 hasRelatedWork W2050645819 @default.
- W1609376551 hasRelatedWork W2086925712 @default.
- W1609376551 hasRelatedWork W2088719831 @default.
- W1609376551 hasRelatedWork W2224319365 @default.
- W1609376551 hasRelatedWork W2321341844 @default.
- W1609376551 hasRelatedWork W2394598775 @default.
- W1609376551 hasRelatedWork W2416540179 @default.
- W1609376551 hasRelatedWork W2477020619 @default.
- W1609376551 hasRelatedWork W2747344780 @default.
- W1609376551 hasVolume "86" @default.
- W1609376551 isParatext "false" @default.
- W1609376551 isRetracted "false" @default.
- W1609376551 magId "1609376551" @default.
- W1609376551 workType "article" @default.