Matches in SemOpenAlex for { <https://semopenalex.org/work/W1609496572> ?p ?o ?g. }
- W1609496572 abstract "Glutathione (GSH) is the main nonprotein thiol in cells whose functions are dependent on the redox-active thiol of its cysteine moiety that serves as a cofactor for a number of antioxidant and detoxifying enzymes. While synthesized exclusively in the cytosol from its constituent amino acids, GSH is distributed in different compartments, including mitochondria where its concentration in the matrix equals that of the cytosol. This feature and its negative charge at physiological pH imply the existence of specific carriers to import GSH from the cytosol to the mitochondrial matrix, where it plays a key role in defense against respiration-induced reactive oxygen species and in the detoxification of lipid hydroperoxides and electrophiles. Moreover, as mitochondria play a central strategic role in the activation and mode of cell death, mitochondrial GSH has been shown to critically regulate the level of sensitization to secondary hits that induce mitochondrial membrane permeabilization and release of proteins confined in the intermembrane space that once in the cytosol engage the molecular machinery of cell death. In this review, we summarize recent data on the regulation of mitochondrial GSH and its role in cell death and prevalent human diseases, such as cancer, fatty liver disease and Alzheimer’s disease." @default.
- W1609496572 created "2016-06-24" @default.
- W1609496572 creator A5032685023 @default.
- W1609496572 creator A5058717462 @default.
- W1609496572 creator A5080875810 @default.
- W1609496572 date "2014-07-01" @default.
- W1609496572 modified "2023-10-18" @default.
- W1609496572 title "Glutathione and mitochondria" @default.
- W1609496572 cites W100954608 @default.
- W1609496572 cites W1480948328 @default.
- W1609496572 cites W1503983308 @default.
- W1609496572 cites W1512824421 @default.
- W1609496572 cites W1523213544 @default.
- W1609496572 cites W1554372630 @default.
- W1609496572 cites W1580569750 @default.
- W1609496572 cites W1595640022 @default.
- W1609496572 cites W1604304380 @default.
- W1609496572 cites W1766411976 @default.
- W1609496572 cites W1964483580 @default.
- W1609496572 cites W1964774699 @default.
- W1609496572 cites W1964822121 @default.
- W1609496572 cites W1968373312 @default.
- W1609496572 cites W1969024223 @default.
- W1609496572 cites W1970094644 @default.
- W1609496572 cites W1971608015 @default.
- W1609496572 cites W1972907759 @default.
- W1609496572 cites W1973109581 @default.
- W1609496572 cites W1974511187 @default.
- W1609496572 cites W1976072602 @default.
- W1609496572 cites W1976087136 @default.
- W1609496572 cites W1977258127 @default.
- W1609496572 cites W1978631832 @default.
- W1609496572 cites W1979710854 @default.
- W1609496572 cites W1980429333 @default.
- W1609496572 cites W1980763538 @default.
- W1609496572 cites W1980792888 @default.
- W1609496572 cites W1983677426 @default.
- W1609496572 cites W1984180526 @default.
- W1609496572 cites W1984486531 @default.
- W1609496572 cites W1984502108 @default.
- W1609496572 cites W1986366581 @default.
- W1609496572 cites W1989719889 @default.
- W1609496572 cites W1991530152 @default.
- W1609496572 cites W1991572345 @default.
- W1609496572 cites W1992915912 @default.
- W1609496572 cites W1993238109 @default.
- W1609496572 cites W1993668532 @default.
- W1609496572 cites W1994442108 @default.
- W1609496572 cites W1996099843 @default.
- W1609496572 cites W1996335285 @default.
- W1609496572 cites W1997171049 @default.
- W1609496572 cites W1997574987 @default.
- W1609496572 cites W1998019353 @default.
- W1609496572 cites W1998655683 @default.
- W1609496572 cites W2001340083 @default.
- W1609496572 cites W2002490399 @default.
- W1609496572 cites W2002860741 @default.
- W1609496572 cites W2003310438 @default.
- W1609496572 cites W2005028774 @default.
- W1609496572 cites W2005904769 @default.
- W1609496572 cites W2006313098 @default.
- W1609496572 cites W2010023860 @default.
- W1609496572 cites W2010101404 @default.
- W1609496572 cites W2010712769 @default.
- W1609496572 cites W2011006339 @default.
- W1609496572 cites W2011555635 @default.
- W1609496572 cites W2013049918 @default.
- W1609496572 cites W2013194090 @default.
- W1609496572 cites W2016002923 @default.
- W1609496572 cites W2016031481 @default.
- W1609496572 cites W2017275974 @default.
- W1609496572 cites W2018427017 @default.
- W1609496572 cites W2018490812 @default.
- W1609496572 cites W2020804797 @default.
- W1609496572 cites W2022211348 @default.
- W1609496572 cites W2025532989 @default.
- W1609496572 cites W2025698440 @default.
- W1609496572 cites W2029017865 @default.
- W1609496572 cites W2029288288 @default.
- W1609496572 cites W2030727312 @default.
- W1609496572 cites W2030870722 @default.
- W1609496572 cites W2032327447 @default.
- W1609496572 cites W2034871552 @default.
- W1609496572 cites W2035503754 @default.
- W1609496572 cites W2036167505 @default.
- W1609496572 cites W2036810172 @default.
- W1609496572 cites W2038597127 @default.
- W1609496572 cites W2039510157 @default.
- W1609496572 cites W2039877291 @default.
- W1609496572 cites W2040566047 @default.
- W1609496572 cites W2041298355 @default.
- W1609496572 cites W2043121948 @default.
- W1609496572 cites W2043472746 @default.
- W1609496572 cites W2045807797 @default.
- W1609496572 cites W2046795038 @default.
- W1609496572 cites W2046966098 @default.
- W1609496572 cites W2047613132 @default.
- W1609496572 cites W2047651678 @default.
- W1609496572 cites W2048210493 @default.
- W1609496572 cites W2048456744 @default.