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- W1609944181 abstract "Identification of the amino acid residue located at the nucleotide- or sugar nucleotide-binding site is prerequisite for structure–function studies of many proteins that bind nucleotide or sugar nucleotide. Affinity labeling might be the most convenient method for this purpose. Although there are many affinity labels available, a new class of pyridoxal polyphosphoryl derivatives of nucleotides is introduced as efficient active-site probes for nucleotide- or sugar nucleotide-binding enzymes. One of the members of this new class is pyridoxal 5'-diphospho-5'-uridine which is used to identify a lysyl residue located at or near the uridine diphosphoglucose-binding site in rabbit muscle glycogen synthase. Incubation of the enzyme with this reagent results in rapid inactivation in a time- and dose-dependent manner. Reagents containing more phosphate groups, for example, pyridoxal 5'-triphospho-5'-adenosine and pyridoxal 5'-tetraphospho-5'-adenosine are also synthesized and used as affinity labels. Because all of these reagents are structurally closely related to the natural nucleotides or sugar nucleotides, they exhibit high affinity for nucleotide- and sugar nucleotide-binding proteins." @default.
- W1609944181 created "2016-06-24" @default.
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- W1609944181 date "1997-01-01" @default.
- W1609944181 modified "2023-10-17" @default.
- W1609944181 title "[5] Synthesis and application of pyridoxal polyphosphoryl derivatives as active-site probes for nucleotide-binding enzymes" @default.
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- W1609944181 doi "https://doi.org/10.1016/s0076-6879(97)80099-7" @default.
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