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- W1609965130 endingPage "201" @default.
- W1609965130 startingPage "183" @default.
- W1609965130 abstract "This chapter focuses on the glutamate receptors that are concentrated in the postsynaptic membrane. Postsynaptic glutamate receptors are classified as ionotropic receptors (iGluRs) that may be further divided into N-methyl-D-aspartate (NMDA) receptors, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, kainate receptors, and delta receptors; and metabotropic receptors (mGluRs). The group I mGluRs, mGluRα and mGluR5, which are linked to phospholipase C (PLC) and phosphoinositide turnover, are predominant at postsynaptic sites. Both iGluRs and mGluRs are investigated at the biophysical, pharmacological, and electrophysiological levels, both in native preparations and in heterologous expression systems. Glutamate receptors are specifically targeted to postsynaptic domains in neurons and even to subdomains within the postsynaptic specialization. At these specialized microdomains, glutamate receptors are associated with specific cytoplasmic proteins that link them to the cytoskeleton and to the intracellular signal transduction pathways. Binding to specific intracellular proteins is important for immobilization and clustering of glutamate receptors for their correct localization at postsynaptic sites, for their ability to transmit signals to appropriate cytoplasmic pathways, and for functional modulation of the receptors by kinases, phosphatases, and other regulatory proteins." @default.
- W1609965130 created "2016-06-24" @default.
- W1609965130 creator A5008631765 @default.
- W1609965130 creator A5048226735 @default.
- W1609965130 date "2000-01-01" @default.
- W1609965130 modified "2023-09-27" @default.
- W1609965130 title "Chapter VI Targeting and anchoring of glutamate receptors and associated signaling molecules" @default.
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