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- W1610174310 abstract "by an increase in the firing frequency (from 1.5 to 4.9 action potentials/s). In 3 of 9 neurons tested (33%), GLP-1 induced hyperpolarization (from 59.7±2.2mV to 66.9±6.8mV) and a decrease in the firing frequency (from 1.1±0.07 to 0.3±0.07 action potentials/s). GLP-1 had no effect on the resting membrane potential or the firing frequency of the remaining 5 neurons. In 5 neurons, the effects of GLP-1 on spontaneous excitatory postsynaptic potentials (sEPSC) were investigated. GLP-1 decreased the sEPSC frequency in only 1 neuron (from 2.32 to 0.58 pulses per second), leaving the remaining 4 neurons unaffected. Our data show that, in contrast to normoglycemic animals, GLP-1 increases the firing frequency and synaptic transmission of only a small proportion of neurons in diabetic mice. These results suggest that loss of sensitivity to GLP-1 of DMV neurons may contribute to the dysfunction of gastrointestinal and pancreatic regulation in diabetic animals. Supported by NIH DK078364 to KNB" @default.
- W1610174310 created "2016-06-24" @default.
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- W1610174310 date "2011-05-01" @default.
- W1610174310 modified "2023-09-25" @default.
- W1610174310 title "Loss of Glucose-Induced Modulation of Vagal Afferent Neurotransmission in a Mouse Model of Type 1 Diabetes" @default.
- W1610174310 doi "https://doi.org/10.1016/s0016-5085(11)63461-6" @default.
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