Matches in SemOpenAlex for { <https://semopenalex.org/work/W1610305067> ?p ?o ?g. }
- W1610305067 endingPage "663" @default.
- W1610305067 startingPage "650" @default.
- W1610305067 abstract "Abstract Characteristics of reactive oxygen species (ROS) production in isolated guinea‐pig brain mitochondria respiring on α‐glycerophosphate (α‐GP) were investigated and compared with those supported by succinate. Mitochondria established a membrane potential (ΔΨ m ) and released H 2 O 2 in parallel with an increase in NAD(P)H fluorescence in the presence of α‐GP (5–40 m m ). H 2 O 2 formation and the increase in NAD(P)H level were inhibited by rotenone, ADP or FCCP, respectively, being consistent with a reverse electron transfer (RET). The residual H 2 O 2 formation in the presence of FCCP was stimulated by myxothiazol in mitochondria supported by α‐GP, but not by succinate. ROS under these conditions are most likely to be derived from α‐GP‐dehydrogenase. In addition, huge ROS formation could be provoked by antimycin in α‐GP‐supported mitochondria, which was prevented by myxothiazol, pointing to the generation of ROS at the quinol‐oxidizing center (Q o ) site of complex III. FCCP further stimulated the production of ROS to the highest rate that we observed in this study. We suggest that the metabolism of α‐GP leads to ROS generation primarily by complex I in RET, and in addition a significant ROS formation could be ascribed to α‐GP‐dehydrogenase in mammalian brain mitochondria. ROS generation by α‐GP at complex III is evident only when this complex is inhibited by antimycin." @default.
- W1610305067 created "2016-06-24" @default.
- W1610305067 creator A5010858573 @default.
- W1610305067 creator A5025971640 @default.
- W1610305067 creator A5053144324 @default.
- W1610305067 creator A5087841767 @default.
- W1610305067 date "2006-10-05" @default.
- W1610305067 modified "2023-10-16" @default.
- W1610305067 title "Characteristics of ?-glycerophosphate-evoked H<sub>2</sub>O<sub>2</sub>generation in brain mitochondria" @default.
- W1610305067 cites W1488079166 @default.
- W1610305067 cites W1505281105 @default.
- W1610305067 cites W1554017667 @default.
- W1610305067 cites W1565127991 @default.
- W1610305067 cites W1576822037 @default.
- W1610305067 cites W1583826497 @default.
- W1610305067 cites W1585360791 @default.
- W1610305067 cites W1585781020 @default.
- W1610305067 cites W1592590408 @default.
- W1610305067 cites W1850791929 @default.
- W1610305067 cites W1925799544 @default.
- W1610305067 cites W1966448402 @default.
- W1610305067 cites W1981012345 @default.
- W1610305067 cites W1984156662 @default.
- W1610305067 cites W1984156802 @default.
- W1610305067 cites W1985977889 @default.
- W1610305067 cites W1986790448 @default.
- W1610305067 cites W1993742623 @default.
- W1610305067 cites W1996338594 @default.
- W1610305067 cites W1997757821 @default.
- W1610305067 cites W2006485862 @default.
- W1610305067 cites W2017510984 @default.
- W1610305067 cites W2018617232 @default.
- W1610305067 cites W2024267786 @default.
- W1610305067 cites W2025152430 @default.
- W1610305067 cites W2027671847 @default.
- W1610305067 cites W2036127346 @default.
- W1610305067 cites W2043830216 @default.
- W1610305067 cites W2043956498 @default.
- W1610305067 cites W2048825417 @default.
- W1610305067 cites W2050357506 @default.
- W1610305067 cites W2051886358 @default.
- W1610305067 cites W2052252788 @default.
- W1610305067 cites W2052406949 @default.
- W1610305067 cites W2056629509 @default.
- W1610305067 cites W2058106189 @default.
- W1610305067 cites W2063585967 @default.
- W1610305067 cites W2071469250 @default.
- W1610305067 cites W2079762064 @default.
- W1610305067 cites W2086276885 @default.
- W1610305067 cites W2087561593 @default.
- W1610305067 cites W2089663038 @default.
- W1610305067 cites W2092645565 @default.
- W1610305067 cites W2092715210 @default.
- W1610305067 cites W2096686378 @default.
- W1610305067 cites W2111757377 @default.
- W1610305067 cites W2112696881 @default.
- W1610305067 cites W2146508536 @default.
- W1610305067 cites W2147849026 @default.
- W1610305067 cites W2157742682 @default.
- W1610305067 cites W2166044246 @default.
- W1610305067 cites W2167734608 @default.
- W1610305067 cites W2168208715 @default.
- W1610305067 cites W2271272206 @default.
- W1610305067 cites W2336962972 @default.
- W1610305067 cites W2338434618 @default.
- W1610305067 cites W2414123687 @default.
- W1610305067 cites W2783716685 @default.
- W1610305067 cites W4231181883 @default.
- W1610305067 cites W2045633855 @default.
- W1610305067 doi "https://doi.org/10.1111/j.1471-4159.2006.04223.x" @default.
- W1610305067 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17263793" @default.
- W1610305067 hasPublicationYear "2006" @default.
- W1610305067 type Work @default.
- W1610305067 sameAs 1610305067 @default.
- W1610305067 citedByCount "103" @default.
- W1610305067 countsByYear W16103050672012 @default.
- W1610305067 countsByYear W16103050672013 @default.
- W1610305067 countsByYear W16103050672014 @default.
- W1610305067 countsByYear W16103050672015 @default.
- W1610305067 countsByYear W16103050672016 @default.
- W1610305067 countsByYear W16103050672017 @default.
- W1610305067 countsByYear W16103050672018 @default.
- W1610305067 countsByYear W16103050672019 @default.
- W1610305067 countsByYear W16103050672020 @default.
- W1610305067 countsByYear W16103050672021 @default.
- W1610305067 countsByYear W16103050672022 @default.
- W1610305067 countsByYear W16103050672023 @default.
- W1610305067 crossrefType "journal-article" @default.
- W1610305067 hasAuthorship W1610305067A5010858573 @default.
- W1610305067 hasAuthorship W1610305067A5025971640 @default.
- W1610305067 hasAuthorship W1610305067A5053144324 @default.
- W1610305067 hasAuthorship W1610305067A5087841767 @default.
- W1610305067 hasBestOaLocation W16103050671 @default.
- W1610305067 hasConcept C181199279 @default.
- W1610305067 hasConcept C185592680 @default.
- W1610305067 hasConcept C2778175917 @default.
- W1610305067 hasConcept C2778389096 @default.
- W1610305067 hasConcept C2779965811 @default.