FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1610329392> ?p ?o ?g. }

• W1610329392 endingPage "1072" @default.
• W1610329392 startingPage "1065" @default.
• W1610329392 abstract "Amphetamineanalogs have emerged as popular recreational drugs of abuse. The number of reports of these substances producing severe acute toxicity and death is increasing. In 'Ecstasy' -associated deaths, focal necrosis in the liver and individual myocytic necrosis has been reported. Furthermore, serotonergic and dopaminergic neuronal cell damage has been observed in experimental amphetamine intoxication in laboratory animals. Here we demonstrate that subchronic exposure to D-amphetamine, methamphetamine, methylenedioxyamphetamine, and methylenedioxymethamphetamine ('Ecstasy') results in significant neurotoxicity in rat neocortical neurons in vitro. This neuronal cell death is accompanied by endonucleosomal DNA cleavage and differential expression of anti- and proapoptotic bcl-xL/S splice variants. In addition, we observed pronounced induction of cell stress-associated transcription factor c-jun and translation initiation inhibitor p97 after amphetamine treatment. These data support that the neurotoxic effects of different amphetamines are extended to rat neocortical neurons and that apoptotic pathways are involved in amphetamine-induced neurotoxicity." @default.
• W1610329392 created "2016-06-24" @default.
• W1610329392 creator A5007928161 @default.
• W1610329392 creator A5024681233 @default.
• W1610329392 creator A5036654338 @default.
• W1610329392 creator A5059725882 @default.
• W1610329392 creator A5066818094 @default.
• W1610329392 creator A5070929886 @default.
• W1610329392 creator A5031206147 @default.
• W1610329392 date "1999-06-01" @default.
• W1610329392 modified "2023-10-16" @default.
• W1610329392 title "Amphetamines induce apoptosis and regulation of bcl‐x splice variants in neocortical neurons" @default.
• W1610329392 cites W1503813864 @default.
• W1610329392 cites W1884253425 @default.
• W1610329392 cites W1992372396 @default.
• W1610329392 cites W1994609038 @default.
• W1610329392 cites W2000894919 @default.
• W1610329392 cites W2001289498 @default.
• W1610329392 cites W2003063237 @default.
• W1610329392 cites W2004126223 @default.
• W1610329392 cites W2014460982 @default.
• W1610329392 cites W2021770828 @default.
• W1610329392 cites W2022738484 @default.
• W1610329392 cites W2035325069 @default.
• W1610329392 cites W2038399319 @default.
• W1610329392 cites W2043845653 @default.
• W1610329392 cites W2047944520 @default.
• W1610329392 cites W2052124305 @default.
• W1610329392 cites W2053264627 @default.
• W1610329392 cites W2058338796 @default.
• W1610329392 cites W2070478389 @default.
• W1610329392 cites W2083555350 @default.
• W1610329392 cites W2084240094 @default.
• W1610329392 cites W2095188030 @default.
• W1610329392 cites W2098553579 @default.
• W1610329392 cites W2107854911 @default.
• W1610329392 cites W2129271181 @default.
• W1610329392 cites W2159380021 @default.
• W1610329392 cites W2161690623 @default.
• W1610329392 cites W2165399098 @default.
• W1610329392 cites W2171847604 @default.
• W1610329392 doi "https://doi.org/10.1096/fasebj.13.9.1065" @default.
• W1610329392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10336889" @default.
• W1610329392 hasPublicationYear "1999" @default.
• W1610329392 type Work @default.
• W1610329392 sameAs 1610329392 @default.
• W1610329392 citedByCount "170" @default.
• W1610329392 countsByYear W16103293922012 @default.
• W1610329392 countsByYear W16103293922013 @default.
• W1610329392 countsByYear W16103293922014 @default.
• W1610329392 countsByYear W16103293922015 @default.
• W1610329392 countsByYear W16103293922016 @default.
• W1610329392 countsByYear W16103293922017 @default.
• W1610329392 countsByYear W16103293922018 @default.
• W1610329392 countsByYear W16103293922019 @default.
• W1610329392 countsByYear W16103293922020 @default.
• W1610329392 countsByYear W16103293922022 @default.
• W1610329392 countsByYear W16103293922023 @default.
• W1610329392 crossrefType "journal-article" @default.
• W1610329392 hasAuthorship W1610329392A5007928161 @default.
• W1610329392 hasAuthorship W1610329392A5024681233 @default.
• W1610329392 hasAuthorship W1610329392A5031206147 @default.
• W1610329392 hasAuthorship W1610329392A5036654338 @default.
• W1610329392 hasAuthorship W1610329392A5059725882 @default.
• W1610329392 hasAuthorship W1610329392A5066818094 @default.
• W1610329392 hasAuthorship W1610329392A5070929886 @default.
• W1610329392 hasBestOaLocation W16103293921 @default.
• W1610329392 hasConcept C118552586 @default.
• W1610329392 hasConcept C126322002 @default.
• W1610329392 hasConcept C137183658 @default.
• W1610329392 hasConcept C166940927 @default.
• W1610329392 hasConcept C169760540 @default.
• W1610329392 hasConcept C170493617 @default.
• W1610329392 hasConcept C178790620 @default.
• W1610329392 hasConcept C185592680 @default.
• W1610329392 hasConcept C190283241 @default.
• W1610329392 hasConcept C2775864247 @default.
• W1610329392 hasConcept C2777193897 @default.
• W1610329392 hasConcept C2779488553 @default.
• W1610329392 hasConcept C2779491297 @default.
• W1610329392 hasConcept C2779989194 @default.
• W1610329392 hasConcept C2780114369 @default.
• W1610329392 hasConcept C2780376393 @default.
• W1610329392 hasConcept C2780876324 @default.
• W1610329392 hasConcept C29730261 @default.
• W1610329392 hasConcept C31573885 @default.
• W1610329392 hasConcept C37000724 @default.
• W1610329392 hasConcept C513476851 @default.
• W1610329392 hasConcept C521977710 @default.
• W1610329392 hasConcept C55493867 @default.
• W1610329392 hasConcept C71924100 @default.
• W1610329392 hasConcept C86803240 @default.
• W1610329392 hasConcept C95444343 @default.
• W1610329392 hasConcept C98274493 @default.
• W1610329392 hasConceptScore W1610329392C118552586 @default.
• W1610329392 hasConceptScore W1610329392C126322002 @default.
• W1610329392 hasConceptScore W1610329392C137183658 @default.
• W1610329392 hasConceptScore W1610329392C166940927 @default.

• next