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- W161058139 abstract "In the history of child psychiatry, pharmacological intervention has followed practice established with adults. This approach is eminently rational because of the reluctance to administer to developing organisms compounds whose effects are not well known in mature humans. Thus, after antipsychotic, antidepressant, and stimulant drugs were found to have valuable properties in adults, they were tried among similar, child, clinical groups. Though the use of imipramine in school-phobic children followed its use in agoraphobic adults (Klein, 1964; Klein & Fink, 1962), its first application was derived from inferences regarding relationships of psychopathology rather than from strict, therapeutic empiricism. The syndrome of agoraphobia was clearly identified long ago, but until recently had received relatively little clinical attention. Agoraphobic adults experience sudden, unexplained, panic attacks and are unable to travel independently. They are typically women. One, Freudian theory posits that the symptoms are due to an unconscious, anxiety-provoking, prostitution wish: the women's phobic avoidance of the outside world prevents the activation of an incompletely repressed wish to be a streetwalker. Fortuitously, Klein discovered that imipramine blocked agoraphobes' apparently spontaneous panic attacks. Double-blind, placebo-controlled studies confirmed this clinical finding (Klein, 1964). Applying an ethological concept to the panic anxiety of agoraphobes, Klein postulated that these patients suffered from a disruption of a normal biological process responsible for the regulation of anxiety triggered by separation. This notion was stimulated by the observation that a large proportion of the patients had a childhood history of severe separation anxiety and that their" @default.
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- W161058139 date "1975-03-01" @default.
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- W161058139 title "Pharmacotherapy and Management of Pathological Separation Anxiety" @default.
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- W161058139 doi "https://doi.org/10.1080/00207411.1975.11448687" @default.
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