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- W161062946 startingPage "379" @default.
- W161062946 abstract "In many ways, osteopontin is an atypical cytokine. From its unusual, flexible structure to its participation in a variety of different systems, the protein almost defies categorization. It clearly meets the criteria for a cytokine (1), and has multiple effects on the immune system. Yet it also regulates mineralization, and is an important component and regulator of normal and abnormal calcified tissues and structures. In addition, it regulates fibrosis in various pathologies, but whether this activity relates to its function as a cytokine is still an open question. Thus the flexibility of the protein structurally is mirrored in its functional flexibility. Osteopontin is a multitasking protein, and since many of its functions have been best defined through analysis of the OPN-knockout mouse, this volume is a most appropriate venue in which to review these functions. Here we review the role of OPN in a number of systems in which it participates, including bone, the immune system, renal and cardiovascular physiology, and tumorigenesis and metastasis, with especial emphasis on studies utilizing the OPN knockout mice. Furthermore, we consider the idea that many of the functions of OPN are mediated by its ability to regulate cellular recruitment." @default.
- W161062946 created "2016-06-24" @default.
- W161062946 creator A5026716633 @default.
- W161062946 creator A5034603708 @default.
- W161062946 creator A5038947295 @default.
- W161062946 date "2003-01-01" @default.
- W161062946 modified "2023-09-23" @default.
- W161062946 title "Osteopontin, a Surprisingly Flexible Cytokine" @default.
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