Matches in SemOpenAlex for { <https://semopenalex.org/work/W1610934367> ?p ?o ?g. }
- W1610934367 endingPage "4243" @default.
- W1610934367 startingPage "4237" @default.
- W1610934367 abstract "Abstract Heat shock proteins assist the survival of Mycobacterium tuberculosis (MTB) but also provide a signal to the immune response. The gene most strongly induced by heat shock in MTB is Rv0251c, which encodes Acr2, a novel member of the α-crystallin family of molecular chaperones. The expression of acr2 increased within 1 h after infection of monocytes or macrophages, reaching a peak of 18- to 55-fold by 24 h. Inhibition of superoxide action reduced the intracellular increase in acr2. Despite this contribution to the stress response of MTB, the gene for acr2 appears dispensable; a deletion mutant (Δacr2) was unimpaired in log phase growth and persisted in IFN-γ-activated human macrophages. Acr2 protein was strongly recognized by cattle with early primary Mycobacterium bovis infection and by healthy MTB-sensitized people. Within the latter group, those with recent exposure to infectious tuberculosis had, on average, 2.6 times the frequency of Acr2-specific IFN-γ-secreting T cells than those with more remote exposure (p = 0.009). These data show that, by its up-regulation early after entry to cells, Acr2 gives away the presence of MTB to the immune response. The demonstration that there is infection stage-specific immunity to tuberculosis has implications for vaccine design." @default.
- W1610934367 created "2016-06-24" @default.
- W1610934367 creator A5000340256 @default.
- W1610934367 creator A5003038620 @default.
- W1610934367 creator A5010264226 @default.
- W1610934367 creator A5011942911 @default.
- W1610934367 creator A5029089921 @default.
- W1610934367 creator A5029827704 @default.
- W1610934367 creator A5030226817 @default.
- W1610934367 creator A5050930070 @default.
- W1610934367 creator A5067976385 @default.
- W1610934367 date "2005-04-01" @default.
- W1610934367 modified "2023-10-16" @default.
- W1610934367 title "Infection Biology of a Novel α-Crystallin of <i>Mycobacterium tuberculosis</i>: Acr2" @default.
- W1610934367 cites W11309145 @default.
- W1610934367 cites W1549522998 @default.
- W1610934367 cites W1562347299 @default.
- W1610934367 cites W1583403909 @default.
- W1610934367 cites W1597808424 @default.
- W1610934367 cites W1607937732 @default.
- W1610934367 cites W1851138068 @default.
- W1610934367 cites W1910931001 @default.
- W1610934367 cites W1987531965 @default.
- W1610934367 cites W1995560626 @default.
- W1610934367 cites W1996511651 @default.
- W1610934367 cites W2007097682 @default.
- W1610934367 cites W2014578355 @default.
- W1610934367 cites W2015014127 @default.
- W1610934367 cites W2045339716 @default.
- W1610934367 cites W2049675690 @default.
- W1610934367 cites W2052791500 @default.
- W1610934367 cites W2065992198 @default.
- W1610934367 cites W2066135800 @default.
- W1610934367 cites W2080689254 @default.
- W1610934367 cites W2082573007 @default.
- W1610934367 cites W2094590640 @default.
- W1610934367 cites W2097858638 @default.
- W1610934367 cites W2120696671 @default.
- W1610934367 cites W2130206397 @default.
- W1610934367 cites W2134631580 @default.
- W1610934367 cites W2137799085 @default.
- W1610934367 cites W2138647657 @default.
- W1610934367 cites W2140354550 @default.
- W1610934367 cites W2144010669 @default.
- W1610934367 cites W2151768664 @default.
- W1610934367 cites W2156436209 @default.
- W1610934367 cites W2156995597 @default.
- W1610934367 cites W2158023121 @default.
- W1610934367 cites W2163167664 @default.
- W1610934367 cites W2163553059 @default.
- W1610934367 cites W2168466885 @default.
- W1610934367 cites W94398733 @default.
- W1610934367 doi "https://doi.org/10.4049/jimmunol.174.7.4237" @default.
- W1610934367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15778386" @default.
- W1610934367 hasPublicationYear "2005" @default.
- W1610934367 type Work @default.
- W1610934367 sameAs 1610934367 @default.
- W1610934367 citedByCount "60" @default.
- W1610934367 countsByYear W16109343672012 @default.
- W1610934367 countsByYear W16109343672013 @default.
- W1610934367 countsByYear W16109343672014 @default.
- W1610934367 countsByYear W16109343672015 @default.
- W1610934367 countsByYear W16109343672016 @default.
- W1610934367 countsByYear W16109343672017 @default.
- W1610934367 countsByYear W16109343672018 @default.
- W1610934367 countsByYear W16109343672019 @default.
- W1610934367 countsByYear W16109343672020 @default.
- W1610934367 countsByYear W16109343672021 @default.
- W1610934367 countsByYear W16109343672022 @default.
- W1610934367 countsByYear W16109343672023 @default.
- W1610934367 crossrefType "journal-article" @default.
- W1610934367 hasAuthorship W1610934367A5000340256 @default.
- W1610934367 hasAuthorship W1610934367A5003038620 @default.
- W1610934367 hasAuthorship W1610934367A5010264226 @default.
- W1610934367 hasAuthorship W1610934367A5011942911 @default.
- W1610934367 hasAuthorship W1610934367A5029089921 @default.
- W1610934367 hasAuthorship W1610934367A5029827704 @default.
- W1610934367 hasAuthorship W1610934367A5030226817 @default.
- W1610934367 hasAuthorship W1610934367A5050930070 @default.
- W1610934367 hasAuthorship W1610934367A5067976385 @default.
- W1610934367 hasBestOaLocation W16109343671 @default.
- W1610934367 hasConcept C104317684 @default.
- W1610934367 hasConcept C142724271 @default.
- W1610934367 hasConcept C153726182 @default.
- W1610934367 hasConcept C159047783 @default.
- W1610934367 hasConcept C203014093 @default.
- W1610934367 hasConcept C205260736 @default.
- W1610934367 hasConcept C2777975735 @default.
- W1610934367 hasConcept C2778497218 @default.
- W1610934367 hasConcept C2779341262 @default.
- W1610934367 hasConcept C2781069245 @default.
- W1610934367 hasConcept C54355233 @default.
- W1610934367 hasConcept C71924100 @default.
- W1610934367 hasConcept C79879829 @default.
- W1610934367 hasConcept C86803240 @default.
- W1610934367 hasConcept C8891405 @default.
- W1610934367 hasConcept C89423630 @default.
- W1610934367 hasConceptScore W1610934367C104317684 @default.