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- W161121754 abstract "This chapter describes the application of spline functions to the pharmacokinetic analysis of methotrexate infused into malignant effusions. It discusses how spline functions can be used in smoothing intrinsically variable data arising from pharmacokinetic experiments. This technique can be especially useful in the initial or exploratory stages of the analyses of such data and can be helpful in ascertaining the suitability of tentatively held models. By providing continuous values of the concentrations and their derivatives through time, the plausibility of a first order linear kinetic model can be examined. A particularly convenient representation for spline functions with a given breakpoint sequence is made by the B-spline basis." @default.
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- W161121754 date "1983-01-01" @default.
- W161121754 modified "2023-09-23" @default.
- W161121754 title "THE APPLICATION OF SPLINE FUNCTIONS TO THE PHARMACOKINETIC ANALYSIS OF METHOTREXATE INFUSED INTO MALIGNANT EFFUSIONS11Supported by National Cancer Institute Grants CA-23100 and CA-23334, National Science Foundation Grants MCS-7901800 and MCS-7906228, and National Institutes of Health Grant CA-26666." @default.
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- W161121754 doi "https://doi.org/10.1016/b978-0-12-589320-6.50029-0" @default.
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