FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1611587415> ?p ?o ?g. }

• W1611587415 endingPage "1534" @default.
• W1611587415 startingPage "1528" @default.
• W1611587415 abstract "Determining the neural mechanisms controlling gonadotrophin-releasing hormone (GnRH) release is of pivotal importance in understanding central control of reproductive physiology in vertebrates. Targeted genetic manipulation of kisspeptin and GPR54 neurons has provided new insights into the mechanisms modulating GnRH release and thereby regulating hypothalamic-pituitary-gonadal axis activity during reproductive maturation. While conditional ablation of the oestrogen receptor α gene in kisspeptin neurons results in a dramatic advancement of the onset of puberty in female mice, subsequent pubertal maturation is arrested in these animals, as they fail to acquire normal ovulatory cyclicity. These data suggest that two oestrogen receptor α-dependent mechanisms, one a 'brake' and the other an 'accelerator', are sequentially operated in kisspeptin neurons during pubertal development of female mice to gate and then to activate GnRH release. In a different experimental approach, we removed entire kisspeptin neurons from the mouse brain and thus from the neural circuits controlling reproduction. Surprisingly, the onset of puberty in females was unaffected by kisspeptin neuron ablation. Furthermore, the animals attained regular ovulatory cyclicity and were fertile. Consistent with this, female mice lacking neurons that express the kisspeptin receptor GPR54 were also fertile, suggesting female reproductive maturation in the absence of kisspeptin/GPR54 signalling. However, acute kisspeptin neuron ablation in adult mice inhibited fertility, indicating that there is developmental compensation for the loss of kisspeptin neurons during reproductive neural circuit formation. Finally, we showed that kisspeptin neurons become an indispensable part of reproductive neural circuitry in the mouse brain before postnatal day 20." @default.
• W1611587415 created "2016-06-24" @default.
• W1611587415 creator A5032575236 @default.
• W1611587415 creator A5033612716 @default.
• W1611587415 date "2013-09-13" @default.
• W1611587415 modified "2023-09-30" @default.
• W1611587415 title "Genetic dissection of puberty in mice" @default.
• W1611587415 cites W1964782601 @default.
• W1611587415 cites W1974869504 @default.
• W1611587415 cites W1977150972 @default.
• W1611587415 cites W1983046294 @default.
• W1611587415 cites W1992041715 @default.
• W1611587415 cites W1992396577 @default.
• W1611587415 cites W1993005991 @default.
• W1611587415 cites W1993413620 @default.
• W1611587415 cites W1993957466 @default.
• W1611587415 cites W2009659460 @default.
• W1611587415 cites W2011056240 @default.
• W1611587415 cites W2019270550 @default.
• W1611587415 cites W2019914463 @default.
• W1611587415 cites W2021996823 @default.
• W1611587415 cites W2029618197 @default.
• W1611587415 cites W2037226098 @default.
• W1611587415 cites W2039254286 @default.
• W1611587415 cites W2040020955 @default.
• W1611587415 cites W2041431942 @default.
• W1611587415 cites W2055956383 @default.
• W1611587415 cites W2061418049 @default.
• W1611587415 cites W2065275835 @default.
• W1611587415 cites W2080303362 @default.
• W1611587415 cites W2081114661 @default.
• W1611587415 cites W2094109313 @default.
• W1611587415 cites W2110656884 @default.
• W1611587415 cites W2111598080 @default.
• W1611587415 cites W2125833216 @default.
• W1611587415 cites W2129890422 @default.
• W1611587415 cites W2138836690 @default.
• W1611587415 cites W2142686356 @default.
• W1611587415 cites W2143506157 @default.
• W1611587415 cites W2158795213 @default.
• W1611587415 cites W2162396585 @default.
• W1611587415 cites W2163470859 @default.
• W1611587415 cites W2170518484 @default.
• W1611587415 cites W2171036048 @default.
• W1611587415 cites W2908833740 @default.
• W1611587415 cites W3023672242 @default.
• W1611587415 doi "https://doi.org/10.1113/expphysiol.2013.071928" @default.
• W1611587415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23955307" @default.
• W1611587415 hasPublicationYear "2013" @default.
• W1611587415 type Work @default.
• W1611587415 sameAs 1611587415 @default.
• W1611587415 citedByCount "10" @default.
• W1611587415 countsByYear W16115874152013 @default.
• W1611587415 countsByYear W16115874152015 @default.
• W1611587415 countsByYear W16115874152016 @default.
• W1611587415 countsByYear W16115874152019 @default.
• W1611587415 countsByYear W16115874152022 @default.
• W1611587415 crossrefType "journal-article" @default.
• W1611587415 hasAuthorship W1611587415A5032575236 @default.
• W1611587415 hasAuthorship W1611587415A5033612716 @default.
• W1611587415 hasBestOaLocation W16115874151 @default.
• W1611587415 hasConcept C126322002 @default.
• W1611587415 hasConcept C134018914 @default.
• W1611587415 hasConcept C169760540 @default.
• W1611587415 hasConcept C170493617 @default.
• W1611587415 hasConcept C2776808119 @default.
• W1611587415 hasConcept C2778794669 @default.
• W1611587415 hasConcept C54355233 @default.
• W1611587415 hasConcept C71315377 @default.
• W1611587415 hasConcept C71924100 @default.
• W1611587415 hasConcept C86803240 @default.
• W1611587415 hasConceptScore W1611587415C126322002 @default.
• W1611587415 hasConceptScore W1611587415C134018914 @default.
• W1611587415 hasConceptScore W1611587415C169760540 @default.
• W1611587415 hasConceptScore W1611587415C170493617 @default.
• W1611587415 hasConceptScore W1611587415C2776808119 @default.
• W1611587415 hasConceptScore W1611587415C2778794669 @default.
• W1611587415 hasConceptScore W1611587415C54355233 @default.
• W1611587415 hasConceptScore W1611587415C71315377 @default.
• W1611587415 hasConceptScore W1611587415C71924100 @default.
• W1611587415 hasConceptScore W1611587415C86803240 @default.
• W1611587415 hasIssue "11" @default.
• W1611587415 hasLocation W16115874151 @default.
• W1611587415 hasLocation W16115874152 @default.
• W1611587415 hasOpenAccess W1611587415 @default.
• W1611587415 hasPrimaryLocation W16115874151 @default.
• W1611587415 hasRelatedWork W1984117810 @default.
• W1611587415 hasRelatedWork W1985335276 @default.
• W1611587415 hasRelatedWork W2005998843 @default.
• W1611587415 hasRelatedWork W2044674226 @default.
• W1611587415 hasRelatedWork W2072695948 @default.
• W1611587415 hasRelatedWork W2166089386 @default.
• W1611587415 hasRelatedWork W2289044528 @default.
• W1611587415 hasRelatedWork W2559075912 @default.
• W1611587415 hasRelatedWork W3004163399 @default.
• W1611587415 hasRelatedWork W3045553629 @default.
• W1611587415 hasVolume "98" @default.
• W1611587415 isParatext "false" @default.

• next