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- W161173757 abstract "L-2-Amino-4-methoxy-cis-but-3-enoic acid was synthesized and found to be an extremely potent inhibitor of ATP: L-methionine adenosyltransferase isozymes of rat liver and Novikoff solid hepatoma. The inhibitory potency of L-2-amino-4-methoxy-cis-but-3-enoic acid was found to be significantly higher than that of its structural analogues, L-methoxinine and L-2-amino-4-methoxy-trans-but-3-enoic acid. The Ki values of L-2-amino-4-methoxy-cis-but-3-enoic acid and the Km values of L-methionine are comparable for the rat liver and tumor isozymes, suggesting a close correlation between the enzyme-bound conformations of these two molecules." @default.
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- W161173757 date "1982-05-01" @default.
- W161173757 modified "2023-10-17" @default.
- W161173757 title "L-2-amino-4-methoxy-cis-but-3-enoic acid, a potent inhibitor of the enzymatic synthesis of S-adenosylmethionine" @default.
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- W161173757 doi "https://doi.org/10.1016/0006-291x(82)91102-0" @default.
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