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- W1611746166 abstract "The present study was designed to characterize adenosine effluxes in the brain using fast scan cyclic voltammetry and explore how spontaneous adenosine release may be affected by a tail pinch. Long Evans rats were anesthetized and a carbon fiber electrode was positioned in the motor cortex or dorsal striatum. Voltammetric recordings were made every 100 ms by applying a triangular waveform from -0.4 to +1.5 V and back versus an Ag/AgCl reference electrode at a rate of 400 V/s. Frequency of adenosine spikes detected was relatively stable in both tested regions and the time intervals between spikes were regular and lasted from 1 to 6 seconds. The number of spikes per 10 seconds ranged from 7.5 ± 0.56 to 9.5 ± 0.62 in the motor cortex and 8.0 ± 1.24 to 9.8 ± 1.54 in the dorsal striatum. The average amplitude fluctuated from 75.0 ± 10.18 to 94.3 ± 18.12 nM in the motor cortex and from 122.7 ± 29.17 to 150.3 ± 43.20 nM in the dorsal striatum. Statistical analysis did not reveal any significant difference in the frequency or the amplitude between the two regions (n=6 rats, p>0.05). The striatal and cortical clearance rate of adenosine was equivalent (n=7 rats, 137.4 ± 23.23 and 195.9 ± 44.14 nM/s for the cortex and striatum, respectively). Furthermore, a 3 s tail pinch transiently increased adenosine signaling in both brain areas. The increase was significantly higher in the dorsal striatum than the motor cortex (n=6, p<0.05). Our study confirmed that adenosine signaling can operate on a faster time scale to modulate brain functions. This study was supported by NIAAA R01AA022449." @default.
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- W1611746166 date "2015-04-01" @default.
- W1611746166 modified "2023-09-27" @default.
- W1611746166 title "Characterization of Real Time Adenosine Effluxes in the Brain of Anesthetized Rats using Fast‐Scan Cyclic Voltammetry" @default.
- W1611746166 doi "https://doi.org/10.1096/fasebj.29.1_supplement.933.1" @default.
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