Matches in SemOpenAlex for { <https://semopenalex.org/work/W1612149354> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W1612149354 endingPage "1369" @default.
- W1612149354 startingPage "1361" @default.
- W1612149354 abstract "Abstract Human neutrophils undergo rapid homologous receptor desensitization following repeated stimulation with chemoattractants such as IL-8, C5a, and FMLP. It has also been demonstrated that cross-desensitization among these chemoattractant receptors occurs. We investigated the mechanisms underlying the cross-desensitization of responses to IL-8 induced by pretreatment with FMLP or C5a. In [125I]-labeled IL-8 binding studies we found that the cross-desensitization induced by FMLP or C5a was associated with a subsequent reduction in IL-8 binding to neutrophils. There was no recovery of [125I]-labeled IL-8 binding on removal of the C5a or FMLP pretreatment. FACS analysis using mAbs specific for the two IL-8R subtypes showed differential regulation of IL-8R A and IL-8R B cell surface expression after chemoattractant pretreatment. Homologous desensitization by IL-8 resulted in internalization of IL-8R A and IL-8R B, but only IL-8R A was completely re-expressed after removal of agonist. FMLP stimulation led to a substantial loss of IL-8R B from the cell surface, whereas C5a stimulation induced only a partial loss. In both cases there was no re-expression of IL-8R B on removal of the chemoattractant stimulation. C5a and FMLP did not affect IL-8R A expression. Calcium mobilization studies using melanoma growth stimulatory activity and IL-8 suggest that a sustained loss of IL-8R B may play a part in maintaining FMLP-induced IL-8R cross-desensitization. Chemoattractant-induced cross-desensitization of neutrophils may be of importance in regulating neutrophil accumulation during the inflammatory response in vivo." @default.
- W1612149354 created "2016-06-24" @default.
- W1612149354 creator A5032808351 @default.
- W1612149354 creator A5075025791 @default.
- W1612149354 creator A5088585001 @default.
- W1612149354 creator A5091004693 @default.
- W1612149354 date "1997-02-01" @default.
- W1612149354 modified "2023-10-17" @default.
- W1612149354 title "Chemoattractant cross-desensitization of the human neutrophil IL-8 receptor involves receptor internalization and differential receptor subtype regulation." @default.
- W1612149354 doi "https://doi.org/10.4049/jimmunol.158.3.1361" @default.
- W1612149354 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9013980" @default.
- W1612149354 hasPublicationYear "1997" @default.
- W1612149354 type Work @default.
- W1612149354 sameAs 1612149354 @default.
- W1612149354 citedByCount "79" @default.
- W1612149354 countsByYear W16121493542012 @default.
- W1612149354 countsByYear W16121493542013 @default.
- W1612149354 countsByYear W16121493542014 @default.
- W1612149354 countsByYear W16121493542015 @default.
- W1612149354 countsByYear W16121493542017 @default.
- W1612149354 countsByYear W16121493542018 @default.
- W1612149354 countsByYear W16121493542021 @default.
- W1612149354 crossrefType "journal-article" @default.
- W1612149354 hasAuthorship W1612149354A5032808351 @default.
- W1612149354 hasAuthorship W1612149354A5075025791 @default.
- W1612149354 hasAuthorship W1612149354A5088585001 @default.
- W1612149354 hasAuthorship W1612149354A5091004693 @default.
- W1612149354 hasBestOaLocation W16121493541 @default.
- W1612149354 hasConcept C134018914 @default.
- W1612149354 hasConcept C139770010 @default.
- W1612149354 hasConcept C170493617 @default.
- W1612149354 hasConcept C24998067 @default.
- W1612149354 hasConcept C2778938600 @default.
- W1612149354 hasConcept C2779779143 @default.
- W1612149354 hasConcept C54166955 @default.
- W1612149354 hasConcept C55493867 @default.
- W1612149354 hasConcept C86803240 @default.
- W1612149354 hasConcept C92759361 @default.
- W1612149354 hasConcept C95444343 @default.
- W1612149354 hasConceptScore W1612149354C134018914 @default.
- W1612149354 hasConceptScore W1612149354C139770010 @default.
- W1612149354 hasConceptScore W1612149354C170493617 @default.
- W1612149354 hasConceptScore W1612149354C24998067 @default.
- W1612149354 hasConceptScore W1612149354C2778938600 @default.
- W1612149354 hasConceptScore W1612149354C2779779143 @default.
- W1612149354 hasConceptScore W1612149354C54166955 @default.
- W1612149354 hasConceptScore W1612149354C55493867 @default.
- W1612149354 hasConceptScore W1612149354C86803240 @default.
- W1612149354 hasConceptScore W1612149354C92759361 @default.
- W1612149354 hasConceptScore W1612149354C95444343 @default.
- W1612149354 hasIssue "3" @default.
- W1612149354 hasLocation W16121493541 @default.
- W1612149354 hasLocation W16121493542 @default.
- W1612149354 hasOpenAccess W1612149354 @default.
- W1612149354 hasPrimaryLocation W16121493541 @default.
- W1612149354 hasRelatedWork W1559212726 @default.
- W1612149354 hasRelatedWork W1612149354 @default.
- W1612149354 hasRelatedWork W2010051217 @default.
- W1612149354 hasRelatedWork W2088072657 @default.
- W1612149354 hasRelatedWork W2111847843 @default.
- W1612149354 hasRelatedWork W2118482528 @default.
- W1612149354 hasRelatedWork W2139994320 @default.
- W1612149354 hasRelatedWork W2561950586 @default.
- W1612149354 hasRelatedWork W3015638568 @default.
- W1612149354 hasRelatedWork W2054405861 @default.
- W1612149354 hasVolume "158" @default.
- W1612149354 isParatext "false" @default.
- W1612149354 isRetracted "false" @default.
- W1612149354 magId "1612149354" @default.
- W1612149354 workType "article" @default.