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- W1612223189 abstract "Pmp3-related proteins are highly conserved proteins that exist in bacteria, yeast, nematodes and plants, whose transcript is regulated in response to abiotic stress like low temperature or high salinity. Pmp3p was originally identified in S. cerevisiae where it belongs to the SNA (Sensitive to Na+) proteins family composed of four members: Pmp3p/Sna1p, Sna2p, Sna3p and Sna4p. Deletion of the PMP3 gene confers sensitivity to cytotoxic cations, while removal of other SNA genes does not lead to a clear phenotypic effect. Pmp3-related proteins may have a common and important role in the modulation of plasma membrane potential and in the regulation of intracellular ion homeostasis. In this study we investigated the functional properties of Pmp3p. We observed increased tolerance of pmp3∆ cells to toxic compound rhodamine 6G, as a consequence of its reduced uptake. Next, we found that cells lacking the PMP3 gene have a lower capacity to develop and maintain plasma membrane potential. In addition, using differential proteomic approach we discovered that Pmp3p regulates the abundance of plasma membrane proteins. For example, deletion of PMP3 decreases the abundance of Pdr5p, Snq2p and other plasma membrane transporters. We propose that the absence of Pmp3p modifies the global organization of the plasma membrane proteome, which in turn affects plasma membrane potential and cellular ion homeostasis." @default.
- W1612223189 created "2016-06-24" @default.
- W1612223189 creator A5057510407 @default.
- W1612223189 date "2013-01-01" @default.
- W1612223189 modified "2023-09-27" @default.
- W1612223189 title "Pmp3p is essential to maintain membrane potential and proteins abundance of the yeast plasma membrane" @default.
- W1612223189 hasPublicationYear "2013" @default.
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