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- W1612231 abstract "The term “peptide growth factors” (PGFs) refers to a group of compounds with peptidic structure that share the ability to regulate cell proliferation and differentiation. In contrast to the classical hormones that are produced and secreted by specific cells, PGFs are usually synthesized by cells of a variety of different tissues, and often exert their pharmacological effects on target cells located not far from the site of release (paracrine response), and sometimes even on the same PGFs-producing cells (autocrine response) (Pimentel, 1994). The list of such compounds is very long and includes well characterized substances, along with others whose characteristics have not been completely elucidated (Pimentel, 1994). The regulation of cell proliferation and differentiation may, however, be just one of several pharmacological effects of PGFs: epidermal growth factor (EGF) and transforming growth factor-a (TGF-a), for example, in addition to stimulating proliferation of epithelial cells of the gastrointestinal (GI) tract, are also potent inhibitors of gastric acid secretion (Elder et al., 1975; Koffman et al., 1982; Guglietta and Lesch, 1993; Guglietta et al., 1994)." @default.
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- W1612231 date "2000-01-01" @default.
- W1612231 modified "2023-10-14" @default.
- W1612231 title "Peptide Growth Factors in Gastrointestinal Disorder Therapeutics" @default.
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- W1612231 doi "https://doi.org/10.1007/978-1-59259-202-9_4" @default.
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