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• W1612401367 abstract "A palyazatban a mesenchymalis őssejteknek (MSC) az immunvalasz kimenetelet befolyasolo faktorait, ezen belul a galektin (Gal)-1 szerepet vizsgaltuk a T sejtek aktivacioja soran. Meghataroztuk a human, illetve eger csontvelői MSC sejtvonalak Gal-1 termeleset, valamint kimutattuk a Gal-1 hianyos eger MSC altal termelt egyeb faktorokat (TGF-beta, COX2, NOS2, IDO es PD-L1). Uj eredmenyeink: -A Gal-1 hozzajarul az MSC antiproliferativ hatasahoz, azonban hianyaban mas immunszuppressziv faktorok is gatoljak a T sejtek osztodasat. Eredmenyeink alapjan sem a Gal-1, sem a PGE2, NO vagy IDO szerepe nem kizarolagos, egyuttes műkodesuk vezet a T sejtek szuppressziojahoz. -Az MSC-termelte Gal-1 kozvetlen sejt-sejt kapcsolatban valtja ki az aktivalt T sejtek pusztulasat, ennek lepesei megegyeznek az alacsony dozisu rekombinans Gal-1 apoptotikus mechanizmusaval. -Diabeteszes egermodellben az MSC pozitiv hatasa nem fugg a Gal-1 termelestől. Mas in vivo kiserletben az MSC kezelese gatolja az egerek anafilaxias reakciojat, es ez a hatas a Gal-1 hianyaban reszben csokken. In vivo nem csak a T sejtek, de egyeb immunsejtek műkodeset is befolyasolja az MSC, mint peldaul a B sejtek ellenanyag-valaszat. Eredmenyeink az mutatjak, hogy az MSC altal termelt Gal-1 immunszuppressziv hatasa nyomon kovethető in vitro tesztekben, de nem minden esetben nyilvanul meg az in vivo esemenyekben. Ez a mesenchymalis őssejtek korultekintő jellemzesenek elvegzesere figyelmeztet a terapias alkalmazasuk előtt. | We examined the immunosuppressive function of MSCs on T cells, focusing on their galectin (Gal)-1 expression. We determined the Gal-1 production of human and mouse bone marrow-derived MSCs, and detected the further immunosuppressive factors (TGF-beta, COX2, NOS2, IDO and PD-L1) expressed by MSCs isolated from Gal-1 knockout mice. Our new results achieved by testing these MSC lines are: -Gal-1 contributes to the anti-proliferative effect of Gal-1, however in the absence of Gal-1 other immunosuppressive factors inhibit the proliferation of T cells. -MSC-derived Gal-1 induces T cell apoptosis in direct cell-to-cell interaction with the same mechanism as recombinant Gal-1 does applied at low concentration. -The positive impact of MSCs on the outcome of diabetes in streptozotocin-treated mice does not depend on their Gal-1 production. In other in vivo experiment, MSCs inhibit the anaphylactic reaction to ovalbumin, and this effect is reduced using Gal-1 knockout MSCs. The in vivo action of MSCs is not restricted on T cells as the antibody production of B cells is also influenced by MSC-derived Gal-1. Our results show that the MSC-derived Gal-1 has an immunosuppressive effect in vitro, however its manifestation is variable in different in vivo experiments. This caution on the thorough characterization of MSCs before their therapeutic use." @default.
• W1612401367 created "2016-06-24" @default.
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• W1612401367 date "2012-01-01" @default.
• W1612401367 modified "2023-09-27" @default.
• W1612401367 title "A galektin-1, mint a mesenchymalis őssejtek által termelt immunszuppresszív faktor = Determining the role of Galectin-1 as an immunosuppressive factor produced by bone marrow derived mesenchymal stem cells" @default.
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